Controlled delivery of taxol from poly(ethylene glycol)-coated poly(lactic acid) microspheres

Gladwin S. Das, Gundu H.R. Rao, Robert F. Wilson, Thomas Chandy

Research output: Contribution to journalArticlepeer-review

39 Scopus citations

Abstract

The development of injectable microspheres for sustained drug delivery to the arterial wall is a major challenge. We demonstrated the possibility of entrapping an antiproliferative agent, taxol, in poly(ethylene glycol) (PEG)coated biodegradable poly(lactic acid) (PLA) microspheres with a mean diameter of 2-6 μm. A solution of taxol and PLA dissolved in an acetone/dichloromethane mixture was poured into an aqueous solution of PEG [or poly(vinyl alcohol) (PVA] with stirring with a high-speed homogenizer for the formation of microspheres. Taxol recovery in PLA-PEG microspheres was higher (61.2 ± 2.3%) than with PVA-based (41.6 ± 1.8%) preparations. An analysis by diffuse reflectance infrared Fourier transform spectroscopy revealed that PEG was incorporated well on the PLA microsphere surface. Scanning electron microscopy revealed that the PEG-coated PLA microspheres were spherical in shape and had a smooth surface texture like those of PVA-based preparations. The amount of drug release was much higher initially (25-30%); this was followed by a constant slow-release profile for a 30-day period of study. This PEG-coated PLA microsphere formulation may have potential for the targeted delivery of antiproliferative agents to treat restenosis.

Original languageEnglish (US)
Pages (from-to)96-103
Number of pages8
JournalJournal of Biomedical Materials Research
Volume55
Issue number1
DOIs
StatePublished - Feb 27 2001

Keywords

  • Drug delivery
  • Microspheres
  • Poly(ethylene glycol)
  • Poly(lactic acid)
  • Taxol

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