Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin

Joseph E. Saavedra; Daniel L. Mooradian; Kelly A. Mowery; Mark H. Schoenfisch; Michael L. Citro; Keith M. Davies; Mark E. Meyerhoff; Larry K. Keefer

doi:10.1016/S0960-894X(00)00086-X

Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin

Joseph E. Saavedra, Daniel L. Mooradian, Kelly A. Mowery, Mark H. Schoenfisch, Michael L. Citro, Keith M. Davies, Mark E. Meyerhoff, Larry K. Keefer

Technological Leadership Institute

Research output: Contribution to journal › Article › peer-review

23 Scopus citations

Abstract

We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they inhibit thrombin-induced blood coagulation. Unlike heparin, they can also inhibit and reverse ADP-induced platelet aggregation (as expected for an NO-releasing agent), suggesting potential utility as dual-action antithrombotics. Published by Elsevier Science Ltd.

Original language	English (US)
Pages (from-to)	751-753
Number of pages	3
Journal	Bioorganic and Medicinal Chemistry Letters
Volume	10
Issue number	8
DOIs	https://doi.org/10.1016/S0960-894X(00)00086-X
State	Published - Apr 2000

Bibliographical note

Funding Information:
The technical assistance of Steven Burris is greatly appreciated. This project was funded in part through NIH grant GM-56991 and by the National Cancer Institute under contract NO1-CO-56000.

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Saavedra, J. E., Mooradian, D. L., Mowery, K. A., Schoenfisch, M. H., Citro, M. L., Davies, K. M., Meyerhoff, M. E., & Keefer, L. K. (2000). Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin. Bioorganic and Medicinal Chemistry Letters, 10(8), 751-753. https://doi.org/10.1016/S0960-894X(00)00086-X

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title = "Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin",

abstract = "We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they inhibit thrombin-induced blood coagulation. Unlike heparin, they can also inhibit and reverse ADP-induced platelet aggregation (as expected for an NO-releasing agent), suggesting potential utility as dual-action antithrombotics. Published by Elsevier Science Ltd.",

author = "Saavedra, {Joseph E.} and Mooradian, {Daniel L.} and Mowery, {Kelly A.} and Schoenfisch, {Mark H.} and Citro, {Michael L.} and Davies, {Keith M.} and Meyerhoff, {Mark E.} and Keefer, {Larry K.}",

note = "Funding Information: The technical assistance of Steven Burris is greatly appreciated. This project was funded in part through NIH grant GM-56991 and by the National Cancer Institute under contract NO1-CO-56000.",

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AU - Saavedra, Joseph E.

AU - Mooradian, Daniel L.

AU - Mowery, Kelly A.

AU - Schoenfisch, Mark H.

AU - Citro, Michael L.

AU - Davies, Keith M.

AU - Meyerhoff, Mark E.

AU - Keefer, Larry K.

N1 - Funding Information: The technical assistance of Steven Burris is greatly appreciated. This project was funded in part through NIH grant GM-56991 and by the National Cancer Institute under contract NO1-CO-56000.

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Y1 - 2000/4

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AB - We describe heparin/diazeniumdiolate conjugates that generate nitric oxide (NO) at physiological pH. Like the heparin from which they were prepared, they inhibit thrombin-induced blood coagulation. Unlike heparin, they can also inhibit and reverse ADP-induced platelet aggregation (as expected for an NO-releasing agent), suggesting potential utility as dual-action antithrombotics. Published by Elsevier Science Ltd.

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Conversion of a polysaccharide to nitric oxide-releasing form. Dual-mechanism anticoagulant activity of diazeniumdiolated heparin

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