Coordination microparticle vaccines engineered from tumor cell templates

Xiaoli Wang, Jiayi Liang, Chuangnian Zhang, Guilei Ma, Chun Wang, Deling Kong

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

A method for encapsulation of individual tumor cells with an epigallocatechin-3-gallate (EGCG)-Al(iii) coordination layer, which can be used as potential tumor vaccines, was developed. The interaction between microparticle vaccines and dendritic cells was investigated in vitro. The microparticles (∼10 μm) were efficiently internalized by DCs with enhanced uptake efficiency via actin polymerization and clathrin-mediated endocytosis.

Original languageEnglish (US)
Pages (from-to)1568-1571
Number of pages4
JournalChemical Communications
Volume55
Issue number11
DOIs
StatePublished - 2019

Bibliographical note

Funding Information:
This work was supported by the National Natural Science Foundation of China (31600743, 81673027), the Natural Science Foundation of Tianjin City (16JCQNJC13900, 18JCQNJC14500), the CAMS Innovation Fund for Medical Sciences (CAMS-I2M-3-026), and the Tianjin Natural Science Fund for Distinguished Young Scholars (17JCJQJC46400).

Publisher Copyright:
© 2019 The Royal Society of Chemistry.

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