Abstract
Described herein is a palladium(II)-catalyzed direct arylation of cyclic enaminones with arylboronic acids. The versatility of this method is that both electron-rich and electron-poor boronic acids can be coupled in high yields. A mixture of two Cu(II) additives was crucial for efficient cross-coupling. The role of each Cu(II) reagent appears to be distinct and complementary serving to assist catalyst reoxidation and transmetalation through a putative arylcopper intermediate.
Original language | English (US) |
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Pages (from-to) | 9496-9503 |
Number of pages | 8 |
Journal | Journal of Organic Chemistry |
Volume | 77 |
Issue number | 21 |
DOIs | |
State | Published - Nov 2 2012 |