TY - JOUR
T1 - Copper complexes with a flexible piperazinyl arm
T2 - nuclearity driven catecholase activity and interactions with biomolecules
AU - Das, Mriganka
AU - Mandal, Poulami
AU - Malviya, Novina
AU - Choudhuri, Indrani
AU - Charmier, Maria Adilia Januário
AU - Morgado, Susana
AU - Mobin, Shaikh M.
AU - Pathak, Biswarup
AU - Mukhopadhyay, Suman
N1 - Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2016/12/16
Y1 - 2016/12/16
N2 - Three new Cu(II) complexes, [Cu(HL1)(pyridine)(H2O)](ClO4)2·2MeOH (1), [Cu2(HL1)2(NO3)2](NO3)2·3H2O (2) and [Cu(HL2)(NO3)2]·MeCN (3), have been synthesized from two Schiff base ligands [HL1 = 1-phenyl-3-((2-(piperazin-4-yl)ethyl)imino)but-1-en-1-ol and HL2 = 4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] using the chair conformer of a flexible piperazinyl moiety. Structural analysis reveals that 1 and 3 are monomeric Cu(II) complexes consisting of five- and six-coordinate Cu(II), respectively, whereas 2 is a dinuclear Cu(II) complex consisting of two different Cu(II) centers, one square planar with the other distorted octahedral. Screening tests were conducted to quantify the binding of 1–3 towards DNA and BSA as well as the DNA cleavage activity of these complexes using gel electrophoresis. Enzyme kinetic studies were also performed for the complexes mimicking catecholase-like activities. Antibacterial activities of these complexes were also examined towards Methicillin-Resistant Staphylococcus aureus bacteria. The results reflect that 2 is more active than the monomeric complexes, which is further corroborated by density functional theory study.
AB - Three new Cu(II) complexes, [Cu(HL1)(pyridine)(H2O)](ClO4)2·2MeOH (1), [Cu2(HL1)2(NO3)2](NO3)2·3H2O (2) and [Cu(HL2)(NO3)2]·MeCN (3), have been synthesized from two Schiff base ligands [HL1 = 1-phenyl-3-((2-(piperazin-4-yl)ethyl)imino)but-1-en-1-ol and HL2 = 4-((2-(piperazin-1-yl)ethyl)imino)pent-2-en-2-ol] using the chair conformer of a flexible piperazinyl moiety. Structural analysis reveals that 1 and 3 are monomeric Cu(II) complexes consisting of five- and six-coordinate Cu(II), respectively, whereas 2 is a dinuclear Cu(II) complex consisting of two different Cu(II) centers, one square planar with the other distorted octahedral. Screening tests were conducted to quantify the binding of 1–3 towards DNA and BSA as well as the DNA cleavage activity of these complexes using gel electrophoresis. Enzyme kinetic studies were also performed for the complexes mimicking catecholase-like activities. Antibacterial activities of these complexes were also examined towards Methicillin-Resistant Staphylococcus aureus bacteria. The results reflect that 2 is more active than the monomeric complexes, which is further corroborated by density functional theory study.
KW - Cu(II) complexes with crystal structure
KW - DNA binding
KW - antimicrobial activity
KW - catecholase like activity
KW - cleavage and BSA binding
KW - computational study
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U2 - 10.1080/00958972.2016.1236193
DO - 10.1080/00958972.2016.1236193
M3 - Article
AN - SCOPUS:84988723473
SN - 0095-8972
VL - 69
SP - 3619
EP - 3637
JO - Journal of Coordination Chemistry
JF - Journal of Coordination Chemistry
IS - 24
ER -