TY - JOUR
T1 - Cord blood transplantation for adults
AU - Brunstein, Claudio G.
AU - Wagner, John E.
PY - 2006/10
Y1 - 2006/10
N2 - Allogeneic haematopoietic stem cell transplant has become an import tool for the treatment of high risk and advanced haematological diseases. However, allogeneic transplantation has been limited by the availability of suitable related and unrelated donors. The positive results with umbilical cord blood as an alternative source of haematopoietic stem cells for transplantation in the paediatric setting encouraged studies in adult patients. In adults, however, the progress of cord blood transplantation has been slower, in part limited by the limitation of cell dose. We review here the current state of the art on cord blood transplantation for adults, and discuss some of the newer strategies being pursued in order to improve its safety and efficacy.
AB - Allogeneic haematopoietic stem cell transplant has become an import tool for the treatment of high risk and advanced haematological diseases. However, allogeneic transplantation has been limited by the availability of suitable related and unrelated donors. The positive results with umbilical cord blood as an alternative source of haematopoietic stem cells for transplantation in the paediatric setting encouraged studies in adult patients. In adults, however, the progress of cord blood transplantation has been slower, in part limited by the limitation of cell dose. We review here the current state of the art on cord blood transplantation for adults, and discuss some of the newer strategies being pursued in order to improve its safety and efficacy.
KW - Myeloablative transplantation
KW - Non-myeloablative transplantation
KW - Umbilical cord blood
UR - http://www.scopus.com/inward/record.url?scp=33748421928&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33748421928&partnerID=8YFLogxK
U2 - 10.1111/j.1423-0410.2006.00823.x
DO - 10.1111/j.1423-0410.2006.00823.x
M3 - Review article
C2 - 16958831
AN - SCOPUS:33748421928
SN - 0042-9007
VL - 91
SP - 195
EP - 205
JO - Vox Sanguinis
JF - Vox Sanguinis
IS - 3
ER -