Coronary artery disease in young women and men with long-standing insulin-dependent diabetes

Stacy Dickinson, Tyson Rogers, Bert Kasiske, Stefan Bertog, George Tadros, Jamil Malik, Robert Wilson, Carmelo Panetta

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

The prevalence and predictors of coronary artery disease were examined in people aged 40 years and younger with insulin-dependent diabetes mellitus. Analysis was performed on those who presented between 1999 and 2003 for kidney and/or pancreas transplant at the University of Minnesota, as all patients who have diabetes mellitus are required to have perioperative cardiology evaluation. The mean age was 33.5 ± 4.4 years for 88 subjects, all had insulin-dependent diabetes mellitus, and 33% were dialysis dependent. Severe coronary artery disease was found in 18.2% of women and in 24.2% of men. Three-vessel coronary artery disease trended less in women (9.1%) compared with men (12.1%). Multivariate predictors for severe and 3-vessel coronary artery disease included prior coronary artery disease, hypertension duration, and ST-T wave changes on electrocardiogram. Coronary artery disease is twice as high as expected in young woman. Studies on early management for atherosclerosis are warranted in this high-risk population.

Original languageEnglish (US)
Pages (from-to)9-15
Number of pages7
JournalAngiology
Volume59
Issue number1
DOIs
StatePublished - Feb 2008

Keywords

  • Coronary artery disease
  • Insulin-dependent diabetes mellitus
  • Young people

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