TY - JOUR
T1 - Corpus callosum morphology in attention deficit-hyperactivity disorder
T2 - morphometric analysis of MRI.
AU - Hynd, G. W.
AU - Semrud-Clikeman, M.
AU - Lorys, A. R.
AU - Novey, E. S.
AU - Eliopulos, D.
AU - Lyytinen, H.
N1 - Copyright:
This record is sourced from MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
PY - 1991/3
Y1 - 1991/3
N2 - Although behavioral evidence provides support for the notion that attention deficit-hyperactivity disorder (ADHD) is related to central nervous system dysfunction, there is little direct evidence to reveal which neurometabolic systems or brain structures are involved. Recent magnetic resonance imaging (MRI) studies suggest that, compared to nondisabled controls, ADHD children may have a smaller right frontal region. Morphometric analysis of MRI scans was used in this exploratory study to determine whether correlated regional variation might exist in the corpus callosum of children with ADHD. While all MRI scans were judged to be clinically normal, morphometric analysis revealed that, compared to nondisabled controls, ADHD children had a smaller corpus callosum, particularly in the region of the genu and splenium, and in the area just anterior to the splenium. Interhemispheric fibers in these regions interconnect the left and right frontal, occipital, parietal, and posterior temporal regions. These results suggest that subtle differences may exist in the brains of children with ADHD and that deviations in normal corticogenesis may underlie the behavioral manifestations of this disorder.
AB - Although behavioral evidence provides support for the notion that attention deficit-hyperactivity disorder (ADHD) is related to central nervous system dysfunction, there is little direct evidence to reveal which neurometabolic systems or brain structures are involved. Recent magnetic resonance imaging (MRI) studies suggest that, compared to nondisabled controls, ADHD children may have a smaller right frontal region. Morphometric analysis of MRI scans was used in this exploratory study to determine whether correlated regional variation might exist in the corpus callosum of children with ADHD. While all MRI scans were judged to be clinically normal, morphometric analysis revealed that, compared to nondisabled controls, ADHD children had a smaller corpus callosum, particularly in the region of the genu and splenium, and in the area just anterior to the splenium. Interhemispheric fibers in these regions interconnect the left and right frontal, occipital, parietal, and posterior temporal regions. These results suggest that subtle differences may exist in the brains of children with ADHD and that deviations in normal corticogenesis may underlie the behavioral manifestations of this disorder.
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U2 - 10.1177/002221949102400302
DO - 10.1177/002221949102400302
M3 - Article
C2 - 2026955
AN - SCOPUS:0026126786
SN - 0022-2194
VL - 24
SP - 141
EP - 146
JO - Journal of Learning Disabilities
JF - Journal of Learning Disabilities
IS - 3
ER -