Measures of excessive daytime sleepiness, neuropsychologic function, and mood were assessed in twenty-two persons with mid-stage Parkinson's disease (PD) and sixteen age-matched healthy controls. Levodopa dose equivalents (LDE) were computed for the patients. While Epworth sleepiness score (ESS), Mini Mental State Exam, logical memory, Stroop, and the mood scales, reliably distinguished patients from controls, only the mood scales (especially anxiety) were reliably associated with ESS. LDE was not significantly associated with ESS. Excessive daytime sleepiness in patients with mid-stage PD may be more strongly related to anxiety than to other neuropsychologic dysfunction or dopaminergic dosing levels.
Bibliographical noteFunding Information:
This material is based upon work supported, in part, by the Office of Research and Development, Medical Research Service, Department of Veteran's Affairs and by the Department of Psychiatry and Behavioral Sciences and the Department of Public Health Sciences, University of California, Davis, CA, USA.
- Dopamine agonists
- Excessive daytime sleepiness
- Executive functions
- Parkinson's disease