Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas

J. H. Kim; J. H. Hur; S. M. Lee; K. S. Im; N. H. Kim; J. H. Sur

doi:10.1016/j.tvjl.2011.10.022

Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas

J. H. Kim, J. H. Hur, S. M. Lee, K. S. Im, N. H. Kim, J. H. Sur

Research output: Contribution to journal › Article › peer-review

26 Scopus citations

Abstract

Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n= 37).Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.

Original language	English (US)
Pages (from-to)	222-227
Number of pages	6
Journal	Veterinary Journal
Volume	193
Issue number	1
DOIs	https://doi.org/10.1016/j.tvjl.2011.10.022
State	Published - Jul 2012
Externally published	Yes

Bibliographical note

Funding Information:
We would like to thank Ms. R.H. Jang for her excellent technical assistance and private animal clinics for providing canine mammary samples. J.H. Hur contributed equally to this paper with the first author. This report represents one part of a PhD thesis by J.H. Hur. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20110021337).

Keywords

Dog
Foxp3
Mammary carcinoma
Prognostic factor
Regulatory T cell

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1016/j.tvjl.2011.10.022

OpenUrl availability

Full text

Cite this

@article{075bba441d3f444096823147b85df364,

title = "Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas",

abstract = "Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n= 37).Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.",

keywords = "Dog, Foxp3, Mammary carcinoma, Prognostic factor, Regulatory T cell",

author = "Kim, {J. H.} and Hur, {J. H.} and Lee, {S. M.} and Im, {K. S.} and Kim, {N. H.} and Sur, {J. H.}",

note = "Funding Information: We would like to thank Ms. R.H. Jang for her excellent technical assistance and private animal clinics for providing canine mammary samples. J.H. Hur contributed equally to this paper with the first author. This report represents one part of a PhD thesis by J.H. Hur. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20110021337).",

year = "2012",

month = jul,

doi = "10.1016/j.tvjl.2011.10.022",

language = "English (US)",

volume = "193",

pages = "222--227",

journal = "Veterinary Journal",

issn = "1090-0233",

publisher = "Bailliere Tindall Ltd",

number = "1",

}

TY - JOUR

T1 - Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas

AU - Kim, J. H.

AU - Hur, J. H.

AU - Lee, S. M.

AU - Im, K. S.

AU - Kim, N. H.

AU - Sur, J. H.

N1 - Funding Information: We would like to thank Ms. R.H. Jang for her excellent technical assistance and private animal clinics for providing canine mammary samples. J.H. Hur contributed equally to this paper with the first author. This report represents one part of a PhD thesis by J.H. Hur. This research was supported by Basic Science Research Program through the National Research Foundation of Korea (NRF) funded by the Ministry of Education, Science and Technology (20110021337).

PY - 2012/7

Y1 - 2012/7

N2 - Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n= 37).Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.

AB - Regulatory T cells (Treg) cells play a crucial role in tumor progression by suppressing anti-tumor immunity, but are not well-documented in veterinary oncology. To identify the characteristics of Treg cells in tumor microenvironments, the numbers of Treg cells were analyzed and compared with histological prognostic factors and molecular biomarkers in canine mammary carcinoma (MC) tissues (n= 37).Abundant Treg cells were associated with high histological grade and lymphatic invasion. The numbers of Treg cells infiltrating intratumoral areas markedly increased in tumors with poor prognostic factors, such as high histological grade, lymphatic invasion, and necrosis. These findings suggest that Treg cells play a role in canine MC progression. Furthermore, Treg cell numbers in intratumoral compartments may provide a potential prognostic factor when assessing canine MCs, which may in turn lead to the development of new immunologic therapeutics.

KW - Dog

KW - Foxp3

KW - Mammary carcinoma

KW - Prognostic factor

KW - Regulatory T cell

UR - http://www.scopus.com/inward/record.url?scp=84863780350&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84863780350&partnerID=8YFLogxK

U2 - 10.1016/j.tvjl.2011.10.022

DO - 10.1016/j.tvjl.2011.10.022

M3 - Article

C2 - 22130461

AN - SCOPUS:84863780350

SN - 1090-0233

VL - 193

SP - 222

EP - 227

JO - Veterinary Journal

JF - Veterinary Journal

IS - 1

ER -

Correlation of Foxp3 positive regulatory T cells with prognostic factors in canine mammary carcinomas

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this