Corticocortical efferent systems in the monkey: A quantitative spatial analysis of the tangential distribution of cells of origin

Roberto Caminiti, Scott Zeger, Paul B. Johnson, Antonio Urbano, Apostolos P. Georgopoulos

Research output: Contribution to journalArticlepeer-review

33 Scopus citations

Abstract

The laminar and tangential distributions of association neurons projecting from areas 4 and 6 of the frontal lobe to area 5 of the superior parietal lobule were studied in macaque monkeys by using horseradish peroxidase histochemistry. In both areas 4 and 6 association neurons were medium‐large pyramidal cells of layers II and III, and pyramidal and fusiform cells of layers V‐VI. Tangentially, they were distributed unevenly over the cortical surface occupying only certain parts of areas 4 and 6, including the dorsomedial part of area 6, the proximal arm region of Woolsey's M1 map, parts of the postarcuate cortex, and the supplementary motor area. Within these projection zones, the number of projection cells waxed and waned in a periodic fashion. Quantitative methods, including spectral analysis techniques, were used to characterize precisely spatial periodicities along the rostrocaudal dimension. The same quantitative analyses were used to determine the nature of the tangential distribution of corticocallosal cells of area 5 projecting to contralateral area 5. Both association and callosal spectra contained a strong component in the range of low spatial frequencies, corresponding to periods greater than 2 mm. Moreover, a consistent peak was observed in both spectra at spatial frequencies corresponding to periods ranging from 0.85 to 1.28 mm. This peak is in accord with the hypothesis of a modular organization of the cells of origin of these projection systems.

Original languageEnglish (US)
Pages (from-to)405-419
Number of pages15
JournalJournal of Comparative Neurology
Volume241
Issue number4
DOIs
StatePublished - Nov 22 1985

Keywords

  • Fourier analysis
  • association efferent zone
  • callosal efferent zone
  • tangential distribution of efferent cortical neurons

Fingerprint

Dive into the research topics of 'Corticocortical efferent systems in the monkey: A quantitative spatial analysis of the tangential distribution of cells of origin'. Together they form a unique fingerprint.

Cite this