Cosinor analysis of 24-hour blood pressure profile in hypertensives before and after treatment with ACE-inhibitor enalapril

J. Siegelova; B. Fiser; J. Dusek; G. Cornelissen; F. Halberg

Cosinor analysis of 24-hour blood pressure profile in hypertensives before and after treatment with ACE-inhibitor enalapril

J. Siegelova, B. Fiser, J. Dusek, G. Cornelissen, F. Halberg

Integrative Biology and Physiology

Research output: Contribution to journal › Article › peer-review

Abstract

The aim of the study was to evaluate the efficiency of the antihypertensive treatment with ACE-inhibitor enalapril in patients with essential hypertension by means of 24-hours ambulatory blood pressure monitoring. Eleven patients were examined after 2 weeks of placebo therapy and after 4 weeks of enalapril (Enalapril Lachema, 12.4 ± 4.1 mg, one day dosis) therapy. For the evaluation of the circadian variation of measured values a single cosinor and population cosinor analysis was used. Enalapril therapy significantly decreased MESOR in systolic (p = 0.03) and diastolic blood pressure (p = 0.02) but not the amplitude and acrophase.

Original language	English (US)
Pages (from-to)	203-206
Number of pages	4
Journal	Eurorehab
Issue number	4
State	Published - Dec 1 1995

Keywords

Ambulatory blood pressure monitoring
Cosinor analysis
Enalapril
Essential hypertension

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AU - Siegelova, J.

AU - Fiser, B.

AU - Dusek, J.

AU - Cornelissen, G.

AU - Halberg, F.

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AB - The aim of the study was to evaluate the efficiency of the antihypertensive treatment with ACE-inhibitor enalapril in patients with essential hypertension by means of 24-hours ambulatory blood pressure monitoring. Eleven patients were examined after 2 weeks of placebo therapy and after 4 weeks of enalapril (Enalapril Lachema, 12.4 ± 4.1 mg, one day dosis) therapy. For the evaluation of the circadian variation of measured values a single cosinor and population cosinor analysis was used. Enalapril therapy significantly decreased MESOR in systolic (p = 0.03) and diastolic blood pressure (p = 0.02) but not the amplitude and acrophase.

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Cosinor analysis of 24-hour blood pressure profile in hypertensives before and after treatment with ACE-inhibitor enalapril

Abstract

Keywords

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