Creation of an NCI comparative brain tumor consortium: Informing the translation of new knowledge from canine to human brain tumor patients

Amy K. Leblanc, Christina Mazcko, Diane E. Brown, Jennifer W. Koehler, Andrew D. Miller, C. Ryan Miller, R. Timothy Bentley, Rebecca A. Packer, Matthew Breen, C. Elizabeth Boudreau, Jonathan M. Levine, R. Mark Simpson, Charles Halsey, William Kisseberth, John H. Rossmeisl, Peter J. Dickinson, Timothy M. Fan, Kara Corps, Kenneth Aldape, Vinay PuduvalliG. Elizabeth Pluhar, Mark R. Gilbert

Research output: Contribution to journalReview articlepeer-review

41 Scopus citations


On September 14-15, 2015, a meeting of clinicians and investigators in the fields of veterinary and human neuro-oncology, clinical trials, neuropathology, and drug development was convened at the National Institutes of Health campus in Bethesda, Maryland. This meeting served as the inaugural event launching a new consortium focused on improving the knowledge, development of, and access to naturally occurring canine brain cancer, specifically glioma, as a model for human disease. Within the meeting, a SWOT (strengths, weaknesses, opportunities, and threats) assessment was undertaken to critically evaluate the role that naturally occurring canine brain tumors could have in advancing this aspect of comparative oncology aimed at improving outcomes for dogs and human beings. A summary of this meeting and subsequent discussion are provided to inform the scientific and clinical community of the potential for this initiative. Canine and human comparisons represent an unprecedented opportunity to complement conventional brain tumor research paradigms, addressing a devastating disease for which innovative diagnostic and treatment strategies are clearly needed.

Original languageEnglish (US)
Pages (from-to)1209-1218
Number of pages10
Issue number9
StatePublished - Sep 1 2016

Bibliographical note

Funding Information:
This research was supported in part by the Intramural Research Program of the National Institutes of Health (NIH), the NCI, and the Center for Cancer Research. The results and interpretations do not reflect the views of the US government. K.C. is a fellow in the NIH Comparative Biomedical Scientist Training Program supported by the National Institute of Neurological Disorders and Stroke, the NCI, and North Carolina State University.

Publisher Copyright:
© 2016 Published by Oxford University Press on behalf of the Society for Neuro-Oncology 2016. This work is written by (a) US Government employee(s) and is in the public domain in the US.


  • comparative oncology
  • glioma
  • translational research

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