CRF antagonist partially reverses CRF- and stress-induced effects on feeding

Dean D. Krahn, Blake A. Gosnell, Martha Grace, Allen S. Levine

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274 Scopus citations

Abstract

Exogenous corticotropin releasing factor (CRF) causes centrally mediated behavioral changes including decreased feeding and increased grooming. These behavioral changes are also seen in response to some stressors. However, the role of endogenous CRF in the behavioral response to stressors has not been investigated fully. We report below our findings on the behavioral effects of alpha-helical CRF (9-41), a recently discovered competitive antagonist of CRF-induced ACTH release. Alpha-helical CRF (9-41) partially reversed the decrement in feeding induced by CRF. Furthermore, the reduction in food intake due to restraint stress was partially reversed by alpha-helical CRF (9-41). These results indicate that changes in endogenous CRF release induced by the restraint Stressor may play a role in stress-induced anorexia.

Original languageEnglish (US)
Pages (from-to)285-289
Number of pages5
JournalBrain Research Bulletin
Volume17
Issue number3
DOIs
StatePublished - Sep 1986

Keywords

  • Alpha-helical
  • CRF
  • CRF (9-41)
  • Stress

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