CRF antagonist partially reverses CRF- and stress-induced effects on feeding

Dean D. Krahn; Blake A. Gosnell; Martha Grace; Allen S. Levine

doi:10.1016/0361-9230(86)90233-9

CRF antagonist partially reverses CRF- and stress-induced effects on feeding

Dean D. Krahn, Blake A. Gosnell, Martha Grace, Allen S. Levine

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281 Scopus citations

Abstract

Exogenous corticotropin releasing factor (CRF) causes centrally mediated behavioral changes including decreased feeding and increased grooming. These behavioral changes are also seen in response to some stressors. However, the role of endogenous CRF in the behavioral response to stressors has not been investigated fully. We report below our findings on the behavioral effects of alpha-helical CRF (9-41), a recently discovered competitive antagonist of CRF-induced ACTH release. Alpha-helical CRF (9-41) partially reversed the decrement in feeding induced by CRF. Furthermore, the reduction in food intake due to restraint stress was partially reversed by alpha-helical CRF (9-41). These results indicate that changes in endogenous CRF release induced by the restraint Stressor may play a role in stress-induced anorexia.

Original language	English (US)
Pages (from-to)	285-289
Number of pages	5
Journal	Brain Research Bulletin
Volume	17
Issue number	3
DOIs	https://doi.org/10.1016/0361-9230(86)90233-9
State	Published - Sep 1986
Externally published	Yes

Bibliographical note

Funding Information:
This work was supported by the VeteransA dministrationM edi-cal Center Researchf unds. We would like to thank JoAnn Tallman for secretarial assistance.

Keywords

Alpha-helical
CRF
CRF (9-41)
Stress

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title = "CRF antagonist partially reverses CRF- and stress-induced effects on feeding",

abstract = "Exogenous corticotropin releasing factor (CRF) causes centrally mediated behavioral changes including decreased feeding and increased grooming. These behavioral changes are also seen in response to some stressors. However, the role of endogenous CRF in the behavioral response to stressors has not been investigated fully. We report below our findings on the behavioral effects of alpha-helical CRF (9-41), a recently discovered competitive antagonist of CRF-induced ACTH release. Alpha-helical CRF (9-41) partially reversed the decrement in feeding induced by CRF. Furthermore, the reduction in food intake due to restraint stress was partially reversed by alpha-helical CRF (9-41). These results indicate that changes in endogenous CRF release induced by the restraint Stressor may play a role in stress-induced anorexia.",

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author = "Krahn, {Dean D.} and Gosnell, {Blake A.} and Martha Grace and Levine, {Allen S.}",

note = "Funding Information: This work was supported by the VeteransA dministrationM edi-cal Center Researchf unds. We would like to thank JoAnn Tallman for secretarial assistance.",

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T1 - CRF antagonist partially reverses CRF- and stress-induced effects on feeding

AU - Krahn, Dean D.

AU - Gosnell, Blake A.

AU - Grace, Martha

AU - Levine, Allen S.

N1 - Funding Information: This work was supported by the VeteransA dministrationM edi-cal Center Researchf unds. We would like to thank JoAnn Tallman for secretarial assistance.

PY - 1986/9

Y1 - 1986/9

N2 - Exogenous corticotropin releasing factor (CRF) causes centrally mediated behavioral changes including decreased feeding and increased grooming. These behavioral changes are also seen in response to some stressors. However, the role of endogenous CRF in the behavioral response to stressors has not been investigated fully. We report below our findings on the behavioral effects of alpha-helical CRF (9-41), a recently discovered competitive antagonist of CRF-induced ACTH release. Alpha-helical CRF (9-41) partially reversed the decrement in feeding induced by CRF. Furthermore, the reduction in food intake due to restraint stress was partially reversed by alpha-helical CRF (9-41). These results indicate that changes in endogenous CRF release induced by the restraint Stressor may play a role in stress-induced anorexia.

AB - Exogenous corticotropin releasing factor (CRF) causes centrally mediated behavioral changes including decreased feeding and increased grooming. These behavioral changes are also seen in response to some stressors. However, the role of endogenous CRF in the behavioral response to stressors has not been investigated fully. We report below our findings on the behavioral effects of alpha-helical CRF (9-41), a recently discovered competitive antagonist of CRF-induced ACTH release. Alpha-helical CRF (9-41) partially reversed the decrement in feeding induced by CRF. Furthermore, the reduction in food intake due to restraint stress was partially reversed by alpha-helical CRF (9-41). These results indicate that changes in endogenous CRF release induced by the restraint Stressor may play a role in stress-induced anorexia.

KW - Alpha-helical

KW - CRF

KW - CRF (9-41)

KW - Stress

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AN - SCOPUS:0022871779

SN - 0361-9230

VL - 17

SP - 285

EP - 289

JO - Brain Research Bulletin

JF - Brain Research Bulletin

IS - 3

ER -

CRF antagonist partially reverses CRF- and stress-induced effects on feeding

Abstract

Bibliographical note

Keywords

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