TY - JOUR
T1 - Cricotracheal resection for adult subglottic stenosis
T2 - Factors predicting treatment failure
AU - Jethwa, Ashok R.
AU - Hasan, Wael
AU - Palme, Carsten E.
AU - Mäkitie, Antti A.
AU - Espin-Garcia, Osvaldo
AU - Goldstein, David P.
AU - Gilbert, Ralph W.
AU - Keshavjee, Shaf
AU - Pierre, Andrew
AU - Gullane, Patrick J.
N1 - Publisher Copyright:
© 2019 The American Laryngological, Rhinological and Otological Society, Inc.
PY - 2020/7/1
Y1 - 2020/7/1
N2 - Objectives/Hypothesis: Identify predictors of decannulation failure after cricotracheal resection (CTR) and thyrotracheal anastomosis (TTA) in patients with subglottic stenosis (SGS). Study Design: Retrospective cohort study. Methods: Charts of patients undergoing CTR and TTA for SGS at the University Health Network, Toronto, Ontario, Canada between 1988 and 2017 were reviewed. Patient, pathology, treatment, and outcome data were collected. The end points for statistical analysis were development of restenosis and permanent tracheostomy. Results: One hundred fourteen patients (n = 114) were eligible for inclusion in this review. The mean age at primary resection was 46.9 years, 95 (83%) were females, and 19 (17%) were males. The rate of restenosis and permanent tracheostomy was 13% and 5%, respectively. Sixty-two patients (54%) underwent a CTR and TTA, and 52 patients (46%) underwent a CTR, laryngofissure, and TTA. Traumatic stenosis (odds ratio [OR] = 10.3, P =.017), longer T-tube duration (OR = 1.2, P =.011), combined glottic/subglottic stenosis (OR = 10.47, P =.010), start of the stenosis at the vocal cords (OR = 6.6, P =.029), postoperative minor complications (OR = 13.6, P =.028), and need for repeat surgery (OR = 44.1, P <.001) were associated with an increased risk of requiring permanent tracheostomy. Conclusions: CTR and TTA are excellent surgical approaches for adult patients with subglottic stenosis. In this study, 5% of patients required permanent tracheostomy. Factors predicting treatment failure include traumatic stenosis, longer T-tube duration, combined glottic/subglottic stenosis, start of stenosis at the level of vocal cords, postoperative minor complications, and need for repeat surgery. Level of Evidence: 4 Laryngoscope, 130:1634–1639, 2020.
AB - Objectives/Hypothesis: Identify predictors of decannulation failure after cricotracheal resection (CTR) and thyrotracheal anastomosis (TTA) in patients with subglottic stenosis (SGS). Study Design: Retrospective cohort study. Methods: Charts of patients undergoing CTR and TTA for SGS at the University Health Network, Toronto, Ontario, Canada between 1988 and 2017 were reviewed. Patient, pathology, treatment, and outcome data were collected. The end points for statistical analysis were development of restenosis and permanent tracheostomy. Results: One hundred fourteen patients (n = 114) were eligible for inclusion in this review. The mean age at primary resection was 46.9 years, 95 (83%) were females, and 19 (17%) were males. The rate of restenosis and permanent tracheostomy was 13% and 5%, respectively. Sixty-two patients (54%) underwent a CTR and TTA, and 52 patients (46%) underwent a CTR, laryngofissure, and TTA. Traumatic stenosis (odds ratio [OR] = 10.3, P =.017), longer T-tube duration (OR = 1.2, P =.011), combined glottic/subglottic stenosis (OR = 10.47, P =.010), start of the stenosis at the vocal cords (OR = 6.6, P =.029), postoperative minor complications (OR = 13.6, P =.028), and need for repeat surgery (OR = 44.1, P <.001) were associated with an increased risk of requiring permanent tracheostomy. Conclusions: CTR and TTA are excellent surgical approaches for adult patients with subglottic stenosis. In this study, 5% of patients required permanent tracheostomy. Factors predicting treatment failure include traumatic stenosis, longer T-tube duration, combined glottic/subglottic stenosis, start of stenosis at the level of vocal cords, postoperative minor complications, and need for repeat surgery. Level of Evidence: 4 Laryngoscope, 130:1634–1639, 2020.
KW - Adult subglottic stenosis
KW - cricotracheal resection
KW - prognostic factors
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U2 - 10.1002/lary.28273
DO - 10.1002/lary.28273
M3 - Review article
C2 - 31498456
AN - SCOPUS:85073941161
SN - 0023-852X
VL - 130
SP - 1634
EP - 1639
JO - Laryngoscope
JF - Laryngoscope
IS - 7
ER -