TY - JOUR
T1 - Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders
T2 - A report of the International Myeloma Working Group
AU - Kyle, Robert A.
AU - Child, J. Anthony
AU - Anderson, Kenneth
AU - Barlogie, Bart
AU - Bataille, Regis
AU - Bensinger, William
AU - Bladé, Joan
AU - Boccadoro, Mario
AU - Dalton, William
AU - Dimopoulos, Meletios
AU - Djulbegovic, Benjamin
AU - Drayson, Mark
AU - Durie, Brian
AU - Facon, Thiery
AU - Fonseca, Rafael
AU - Gahrton, Gosta
AU - Greipp, Philip
AU - Harousseau, Jean Luc
AU - Harrington, David
AU - Hussein, Mohamad
AU - Joshua, Douglas
AU - Ludwig, Heinz
AU - Morgan, Gareth
AU - Oken, Martin
AU - Powles, Raymond
AU - Richardson, Paul
AU - Roodman, David
AU - San Miguel, Jesus
AU - Shimizu, Kazuyuki
AU - Shustik, Chaim
AU - Sirohi, Bhawna
AU - Sonneveld, Pieter
AU - Tricot, Guido
AU - Turesson, Ingemar
AU - Van Ness, Brian
AU - Vesole, David
AU - Weber, Donna
AU - Westin, Jan
AU - Wheatley, Keith
PY - 2003/6
Y1 - 2003/6
N2 - The monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells. The characterization of specific entities is an area of difficulty in clinical practice. The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations. In monoclonal gammopathy of undetermined significance (MGUS) or monoclonal gammopathy, unattributed/unassociated (MG[u]), the monoclonal protein is < 30 g/1 and the bone marrow clonal cells < 10% with no evidence of multiple myeloma, other B-cell proliferative disorders or amyloidosis. In asymptomatic (smouldering) myeloma the M-protein is ≥ 30 g/1 and/or bone marrow clonal cells ≥ 10% but no related organ or tissue impairment (ROTI)(end-organ damage), which is typically manifested by increased calcium, renal insufficiency, anaemia, or bone lesions (CRAB) attributed to the plasma cell proliferative process. Symptomatic myeloma requires evidence of ROTL Non-secretory myeloma is characterized by the absence of an M-protein in the serum and urine, bone marrow plasmacytosis and ROTI. Solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas (± recurrent) are also defined as distinct entities. The use of these criteria will facilitate comparison of therapeutic trial data. Evaluation of currently available prognostic factors may allow better definition of prognosis in multiple myeloma.
AB - The monoclonal gammopathies are a group of disorders associated with monoclonal proliferation of plasma cells. The characterization of specific entities is an area of difficulty in clinical practice. The International Myeloma Working Group has reviewed the criteria for diagnosis and classification with the aim of producing simple, easily used definitions based on routinely available investigations. In monoclonal gammopathy of undetermined significance (MGUS) or monoclonal gammopathy, unattributed/unassociated (MG[u]), the monoclonal protein is < 30 g/1 and the bone marrow clonal cells < 10% with no evidence of multiple myeloma, other B-cell proliferative disorders or amyloidosis. In asymptomatic (smouldering) myeloma the M-protein is ≥ 30 g/1 and/or bone marrow clonal cells ≥ 10% but no related organ or tissue impairment (ROTI)(end-organ damage), which is typically manifested by increased calcium, renal insufficiency, anaemia, or bone lesions (CRAB) attributed to the plasma cell proliferative process. Symptomatic myeloma requires evidence of ROTL Non-secretory myeloma is characterized by the absence of an M-protein in the serum and urine, bone marrow plasmacytosis and ROTI. Solitary plasmacytoma of bone, extramedullary plasmacytoma and multiple solitary plasmacytomas (± recurrent) are also defined as distinct entities. The use of these criteria will facilitate comparison of therapeutic trial data. Evaluation of currently available prognostic factors may allow better definition of prognosis in multiple myeloma.
KW - Classification
KW - Gammopathies
KW - Monoclonal
KW - Multiple myeloma
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U2 - 10.1046/j.1365-2141.2003.04355.x
DO - 10.1046/j.1365-2141.2003.04355.x
M3 - Review article
C2 - 12780789
AN - SCOPUS:0038509089
SN - 0007-1048
VL - 121
SP - 749
EP - 757
JO - British journal of haematology
JF - British journal of haematology
IS - 5
ER -