Hydroxyapatite [HAp]/Gelatin [GEL] nanocomposite was prepared at 37 and 48°C through coprecipitation process. The HAp/GEL nanocomposite slurries were cross-linked by imide-based zero-length cross-linking agent such as N-(3-dimethylaminopropyl)-N′-ethylcarbodiimide (EDC) and N-hydroxysuccinimide (NHS). The chemical bond formation and microstructure in HAp/GEL nanocomposite was investigated as a function of cross-linking agents and temperature. The single addition of EDC into the composite slurries resulted in a tougher microstructure in both samples prepared at 37 and 48°C. However, in the case of the simultaneous addition of EDC and NHS the sample prepared at 48°C showed a coarse microstructure. These results were consistent with the fact that the chemical reactivity of NHS is degraded at 48°C whereas the reactivity of EDC increases up to 80°C.
|Original language||English (US)|
|Number of pages||7|
|Journal||Journal of Materials Science: Materials in Medicine|
|State||Published - Oct 1 2007|