TY - JOUR
T1 - Cross-species functional alignment reveals evolutionary hierarchy within the connectome
AU - Xu, Ting
AU - Nenning, Karl Heinz
AU - Schwartz, Ernst
AU - Hong, Seok Jun
AU - Vogelstein, Joshua T.
AU - Goulas, Alexandros
AU - Fair, Damien A.
AU - Schroeder, Charles E.
AU - Margulies, Daniel S.
AU - Smallwood, Jonny
AU - Milham, Michael P.
AU - Langs, Georg
N1 - Publisher Copyright:
© 2020 The Author(s)
PY - 2020/12
Y1 - 2020/12
N2 - Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization reflects a gradient of evolutionary change that decreases from unimodal systems and culminates with the most pronounced changes in posterior regions of the default mode network (angular gyrus, posterior cingulate and middle temporal cortices). Our findings suggest that the establishment of the default mode network, as the apex of a cognitive hierarchy, has changed in a complex manner during human evolution – even within subnetworks.
AB - Evolution provides an important window into how cortical organization shapes function and vice versa. The complex mosaic of changes in brain morphology and functional organization that have shaped the mammalian cortex during evolution, complicates attempts to chart cortical differences across species. It limits our ability to fully appreciate how evolution has shaped our brain, especially in systems associated with unique human cognitive capabilities that lack anatomical homologues in other species. Here, we develop a function-based method for cross-species alignment that enables the quantification of homologous regions between humans and rhesus macaques, even when their location is decoupled from anatomical landmarks. Critically, we find cross-species similarity in functional organization reflects a gradient of evolutionary change that decreases from unimodal systems and culminates with the most pronounced changes in posterior regions of the default mode network (angular gyrus, posterior cingulate and middle temporal cortices). Our findings suggest that the establishment of the default mode network, as the apex of a cognitive hierarchy, has changed in a complex manner during human evolution – even within subnetworks.
KW - Cross-species alignment
KW - Default mode network
KW - Evolution
KW - Hierarchy
KW - Joint embedding
UR - http://www.scopus.com/inward/record.url?scp=85091098401&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85091098401&partnerID=8YFLogxK
U2 - 10.1016/j.neuroimage.2020.117346
DO - 10.1016/j.neuroimage.2020.117346
M3 - Article
C2 - 32916286
AN - SCOPUS:85091098401
SN - 1053-8119
VL - 223
JO - NeuroImage
JF - NeuroImage
M1 - 117346
ER -