Cryptococcal Disease in the Era of "test and Treat": Is There Cause for Concern?

Mahsa Abassi; Joshua Rhein; David B. Meya; David R. Boulware

doi:10.1093/ofid/ofx274

Cryptococcal Disease in the Era of "test and Treat": Is There Cause for Concern?

Mahsa Abassi, Joshua Rhein, David B. Meya, David R. Boulware

Medicine - Infectious Disease and International

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.

Original language	English (US)
Article number	ofx274
Journal	Open Forum Infectious Diseases
Volume	5
Issue number	1
DOIs	https://doi.org/10.1093/ofid/ofx274
State	Published - Jan 1 2018

Bibliographical note

Funding Information:
Financial support. This work was supported by the Fogarty International Center (K01TW010268 and R25TW009345), the National Institute of Neurological Disorders and Stroke (R01NS086312), the National Institute of Allergy and Infectious Diseases (T32AI055433) of the National Institute of Health, and DELTAS Africa Initiative grant No. DEL-15-011 to THRiVE-2 (D.M.).

Publisher Copyright:
© 2017 The Author(s).

Keywords

HIV
cryptococcal immune reconstitution syndrome
test and treat

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access

10.1093/ofid/ofx274

OpenUrl availability

Full text

Cite this

@article{1f6b2668ad66468ca09448e3aa38f9dc,

title = "Cryptococcal Disease in the Era of {"}test and Treat{"}: Is There Cause for Concern?",

abstract = "Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.",

keywords = "HIV, cryptococcal immune reconstitution syndrome, test and treat",

author = "Mahsa Abassi and Joshua Rhein and Meya, {David B.} and Boulware, {David R.}",

note = "Funding Information: Financial support. This work was supported by the Fogarty International Center (K01TW010268 and R25TW009345), the National Institute of Neurological Disorders and Stroke (R01NS086312), the National Institute of Allergy and Infectious Diseases (T32AI055433) of the National Institute of Health, and DELTAS Africa Initiative grant No. DEL-15-011 to THRiVE-2 (D.M.). Publisher Copyright: {\textcopyright} 2017 The Author(s).",

year = "2018",

month = jan,

day = "1",

doi = "10.1093/ofid/ofx274",

language = "English (US)",

volume = "5",

journal = "Open Forum Infectious Diseases",

issn = "2328-8957",

publisher = "Oxford University Press",

number = "1",

}

TY - JOUR

T1 - Cryptococcal Disease in the Era of "test and Treat"

T2 - Is There Cause for Concern?

AU - Abassi, Mahsa

AU - Rhein, Joshua

AU - Meya, David B.

AU - Boulware, David R.

N1 - Funding Information: Financial support. This work was supported by the Fogarty International Center (K01TW010268 and R25TW009345), the National Institute of Neurological Disorders and Stroke (R01NS086312), the National Institute of Allergy and Infectious Diseases (T32AI055433) of the National Institute of Health, and DELTAS Africa Initiative grant No. DEL-15-011 to THRiVE-2 (D.M.). Publisher Copyright: © 2017 The Author(s).

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.

AB - Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.

KW - HIV

KW - cryptococcal immune reconstitution syndrome

KW - test and treat

UR - http://www.scopus.com/inward/record.url?scp=85054414439&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85054414439&partnerID=8YFLogxK

U2 - 10.1093/ofid/ofx274

DO - 10.1093/ofid/ofx274

M3 - Article

C2 - 29372172

AN - SCOPUS:85054414439

SN - 2328-8957

VL - 5

JO - Open Forum Infectious Diseases

JF - Open Forum Infectious Diseases

IS - 1

M1 - ofx274

ER -

Cryptococcal Disease in the Era of "test and Treat": Is There Cause for Concern?

Abstract

Bibliographical note

Keywords

UN SDGs

Access

OpenUrl availability

Other files and links

Fingerprint

Cite this