Treatment of cryptococcosis requires deferred initiation of antiretroviral therapy (ART). Early ART initiation may be detrimental in the context of cryptococcal infection by increasing the risk of immune reconstitution inflammatory syndrome (IRIS). We present 3 cases where early ART initiation in the presence of unrecognized cryptococcal disease had fatal outcomes.
Bibliographical noteFunding Information:
Financial support. This work was supported by the Fogarty International Center (K01TW010268 and R25TW009345), the National Institute of Neurological Disorders and Stroke (R01NS086312), the National Institute of Allergy and Infectious Diseases (T32AI055433) of the National Institute of Health, and DELTAS Africa Initiative grant No. DEL-15-011 to THRiVE-2 (D.M.).
- cryptococcal immune reconstitution syndrome
- test and treat