We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.
Bibliographical noteFunding Information:
Financial support. This work was supported by the National Institute of Neurologic Diseases and Stroke (R01NS086312), the Fogarty International Center (K01TW010268, R25TW009345), the National Institute of Allergy and Infectious Diseases (T32AI055433), the United Kingdom Medical Research Council/DfID/Wellcome Trust Global Clinical Trials (M007413/1), and the Wellcome Trust (210772/Z/18/Z). We thank the University of Minnesota Foundation for provision of the Bactec MGIT culture system for the MSF Epicentre laboratory in Mbarara, Uganda.
- Case series
- Cryptococcal meningitis
- HIV/ AIDS
- Tuberculous meningitis