Cryptococcal Meningitis and Tuberculous Meningitis Co-infection in HIV-Infected Ugandan Adults

Jayne Ellis, Fiona V. Cresswell, Joshua Rhein, Kenneth Ssebambulidde, David R. Boulware

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8 Scopus citations

Abstract

We report 5 HIV-infected Ugandan adults with cryptococcal and tuberculous (TB) meningitis co-infection. All unmasked meningitis occurred within 5 weeks of starting HIV therapy. Xpert MTB/RIF Ultra facilitated prompt diagnosis; however, 60% in-hospital mortality occurred. TB meningitis coinfection prevalence was 0.8% (5/586) among cryptococcal meningitis, 2 during second cryptococcal episodes.

Original languageEnglish (US)
JournalOpen Forum Infectious Diseases
Volume5
Issue number8
DOIs
StatePublished - Aug 1 2018

Bibliographical note

Funding Information:
Financial support. This work was supported by the National Institute of Neurologic Diseases and Stroke (R01NS086312), the Fogarty International Center (K01TW010268, R25TW009345), the National Institute of Allergy and Infectious Diseases (T32AI055433), the United Kingdom Medical Research Council/DfID/Wellcome Trust Global Clinical Trials (M007413/1), and the Wellcome Trust (210772/Z/18/Z). We thank the University of Minnesota Foundation for provision of the Bactec MGIT culture system for the MSF Epicentre laboratory in Mbarara, Uganda.

Keywords

  • Case series
  • Cryptococcal meningitis
  • HIV/ AIDS
  • Tuberculosis
  • Tuberculous meningitis

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