Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution

Juri Katchanov, Cristiane Blechschmidt, Kirsten Nielsen, Gordian Branding, Keikawus Arastéh, Kathrin Tintelnot, Graeme Meintjes, David R. Boulware, Hartmut Stocker

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

We report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.

Original languageEnglish (US)
Pages (from-to)912-914
Number of pages3
JournalInternational Journal of STD and AIDS
Volume26
Issue number12
DOIs
StatePublished - Oct 1 2015

Bibliographical note

Publisher Copyright:
© 2015, The Author(s) 2015.

Keywords

  • AIDS
  • CNS cryptococcosis
  • Cryptococcus neoformans
  • HIV
  • IRIS
  • antiretroviral therapy
  • cryptococcal meningitis
  • immune restoration
  • opportunistic infection

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