Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution

Juri Katchanov; Cristiane Blechschmidt; Kirsten Nielsen; Gordian Branding; Keikawus Arastéh; Kathrin Tintelnot; Graeme Meintjes; David R. Boulware; Hartmut Stocker

doi:10.1177/0956462414563630

Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution

Juri Katchanov, Cristiane Blechschmidt, Kirsten Nielsen, Gordian Branding, Keikawus Arastéh, Kathrin Tintelnot, Graeme Meintjes, David R. Boulware, Hartmut Stocker

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Abstract

We report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.

Original language	English (US)
Pages (from-to)	912-914
Number of pages	3
Journal	International Journal of STD and AIDS
Volume	26
Issue number	12
DOIs	https://doi.org/10.1177/0956462414563630
State	Published - Oct 1 2015

Bibliographical note

Publisher Copyright:
© 2015, The Author(s) 2015.

Keywords

AIDS
CNS cryptococcosis
Cryptococcus neoformans
HIV
IRIS
antiretroviral therapy
cryptococcal meningitis
immune restoration
opportunistic infection

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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abstract = "We report a case of a symptomatic relapse of HIV-related cryptococcal meningoencephalitis eight years after the first diagnosis on the background of immune reconstitution. The findings as well as the clinical course suggests a combination of smouldering localised infection and enhanced inflammatory reaction related to immune restoration due to antiretroviral therapy. A combination of antifungal and anti-inflammatory therapy resulted in clinical and radiological improvement. Our case challenges the concept that immune reconstitution inflammatory syndrome and microbiological relapse are dichotomous entities.",

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AU - Katchanov, Juri

AU - Blechschmidt, Cristiane

AU - Nielsen, Kirsten

AU - Branding, Gordian

AU - Arastéh, Keikawus

AU - Tintelnot, Kathrin

AU - Meintjes, Graeme

AU - Boulware, David R.

AU - Stocker, Hartmut

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Cryptococcal meningoencephalitis relapse after an eight-year delay: an interplay of infection and immune reconstitution

Abstract

Bibliographical note

Keywords

UN SDGs

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