TY - JOUR
T1 - CSF findings in adrenoleukodystrophy
T2 - Correlation between measures of cytokines, IgG production, and disease severity
AU - Phillips, John P.
AU - Lockman, Lawrence A.
AU - Shapiro, Elsa G
AU - Blazar, Bruce R
AU - Loes, Daniel J.
AU - Moser, Hugo W.
AU - Krivit, William
PY - 1994/6
Y1 - 1994/6
N2 - The childhood-onset cerebral form of adrenoleukodystrophy has a devastating neurologic prognosis. Unfortunately, there is no early method of distinguishing it from the more benign forms of adrenoleukodystrophy, such as adrenomyeloneuropathy. To evaluate the manner in which this disease entity may be reflected in the cerebrospinal fluid, we studied a consecutive series of 19 patients, all with biochemically proved adrenoleu-kodystrophy. Total protein, immunoglobulin production, cytokine levels, and cerebrospinal fluid pressure were measured. In this single sample of cerebrospinal fluid, a significant correlation existed between clinical stage of the illness and cerebrospinal fluid myelin basic protein. No correlation existed with total protein, cytokines, or measures of immunoglobulin production.
AB - The childhood-onset cerebral form of adrenoleukodystrophy has a devastating neurologic prognosis. Unfortunately, there is no early method of distinguishing it from the more benign forms of adrenoleukodystrophy, such as adrenomyeloneuropathy. To evaluate the manner in which this disease entity may be reflected in the cerebrospinal fluid, we studied a consecutive series of 19 patients, all with biochemically proved adrenoleu-kodystrophy. Total protein, immunoglobulin production, cytokine levels, and cerebrospinal fluid pressure were measured. In this single sample of cerebrospinal fluid, a significant correlation existed between clinical stage of the illness and cerebrospinal fluid myelin basic protein. No correlation existed with total protein, cytokines, or measures of immunoglobulin production.
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U2 - 10.1016/0887-8994(94)90124-4
DO - 10.1016/0887-8994(94)90124-4
M3 - Article
C2 - 7520699
AN - SCOPUS:0028286132
SN - 0887-8994
VL - 10
SP - 289
EP - 294
JO - Pediatric Neurology
JF - Pediatric Neurology
IS - 4
ER -