CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease

CureGN Consortium

Research output: Contribution to journalArticlepeer-review

17 Scopus citations


Rationale & Objectives: Glomerular diseases, including minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, and immunoglobulin A (IgA) nephropathy, share clinical presentations, yet result from multiple biological mechanisms. Challenges to identifying underlying mechanisms, biomarkers, and new therapies include the rarity of each diagnosis and slow progression, often requiring decades to measure the effectiveness of interventions to prevent end-stage kidney disease (ESKD) or death. Study Design: Multicenter prospective cohort study. Setting & Participants: Cure Glomerulonephropathy (CureGN) will enroll 2,400 children and adults with minimal change disease, focal segmental glomerulosclerosis, membranous nephropathy, or IgA nephropathy (including IgA vasculitis) and a first diagnostic kidney biopsy within 5 years. Patients with ESKD and those with secondary causes of glomerular disease are excluded. Exposures: Clinical data, including medical history, medications, family history, and patient-reported outcomes, are obtained, along with a digital archive of kidney biopsy images and blood and urine specimens at study visits aligned with clinical care 1 to 4 times per year. Outcomes: Patients are followed up for changes in estimated glomerular filtration rate, disease activity, ESKD, and death and for nonrenal complications of disease and treatment, including infection, malignancy, cardiovascular, and thromboembolic events. Analytical Approach: The study design supports multiple longitudinal analyses leveraging the diverse data domains of CureGN and its ancillary program. At 2,400 patients and an average of 2 years’ initial follow-up, CureGN has 80% power to detect an HR of 1.4 to 1.9 for proteinuria remission and a mean difference of 2.1 to 3.0 mL/min/1.73 m2 in estimated glomerular filtration rate per year. Limitations: Current follow-up can only detect large differences in ESKD and death outcomes. Conclusions: Study infrastructure will support a broad range of scientific approaches to identify mechanistically distinct subgroups, identify accurate biomarkers of disease activity and progression, delineate disease-specific treatment targets, and inform future therapeutic trials. CureGN is expected to be among the largest prospective studies of children and adults with glomerular disease, with a broad goal to lessen disease burden and improve outcomes.

Original languageEnglish (US)
Pages (from-to)218-229
Number of pages12
JournalAmerican Journal of Kidney Diseases
Issue number2
StatePublished - Feb 2019

Bibliographical note

Funding Information:
Support: Funding for the CureGN consortium is provided by UM1DK100845 , UM1DK100846 , UM1DK100876 , UM1DK100866 , and UM1DK100867 from the NIDDK . Patient recruitment is supported by NephCure Kidney International. As indicated in the Authors’ Contributions section, NIH staff participated in study design and writing the manuscript. Dates of funding for the first phase of CureGN are September 16, 2013, to May 31, 2019. The funders of this study had no role in study design; collection, analysis, and interpretation of data; writing the report; or the decision to submit the report for publication.

Funding Information:
To maximize use and collaboration around CureGN data sets, a data-sharing and analytic platform was established for use by consortium and ancillary study researchers. TranSMART is an open-source web-based software platform supported by the tranSMART Foundation ( ) and its open-user community. The password-protected CureGN tranSMART platform is loaded with curated clinical data at regular intervals. Analytic tools of the platform can be used to identify subcohorts of interest, generate descriptive statistics, and test associations between data elements. As further data sets are generated (eg, genomics, proteomics, or metabolomics), these data will be available for analysis, allowing scientists with diverse expertise to collaborate efficiently.


  • CureGN
  • Glomerular disease
  • Henoch-Schönlein purpura
  • IgA nephropathy (IgAN)
  • IgA vasculitis (IgAV)
  • adult
  • digital pathology repository
  • estimated glomerular filtration rate (eGFR)
  • focal segmental glomerulosclerosis (FSGS)
  • glomerulonephropathy
  • kidney biopsy
  • longitudinal cohort
  • membranous nephropathy (MN)
  • minimal change disease (MCD)
  • patient-reported outcome (PRO)
  • pediatric
  • study design

Fingerprint Dive into the research topics of 'CureGN Study Rationale, Design, and Methods: Establishing a Large Prospective Observational Study of Glomerular Disease'. Together they form a unique fingerprint.

Cite this