Current understanding of the genetic diversity of Mycobacterium avium subsp. paratuberculosis

Alifiya S. Motiwala, Lingling Li, Vivek Kapur, Srinand Sreevatsan

Research output: Contribution to journalShort surveypeer-review

56 Scopus citations

Abstract

Mycobacterium avium subsp. paratuberculosis (MAP) is the etiological agent of Johne's disease (or paratuberculosis). Paratuberculosis is a chronic gastroenteritis mainly affecting cattle, sheep and other ruminants. MAP is also of concern due to the heretofore unresolved issue of its possible role in Crohn's disease in humans. We present here a review of MAP (i) mobile genetic elements; (ii) repetitive elements; (iii) single nucleotide polymorphisms; and (iv) whole-genome comparisons to study the molecular epidemiology of MAP. A summary of the findings to date is presented, and the discriminatory power, advantage and disadvantages of each of the methods are compared and discussed.

Original languageEnglish (US)
Pages (from-to)1406-1418
Number of pages13
JournalMicrobes and Infection
Volume8
Issue number5
DOIs
StatePublished - Apr 2006

Bibliographical note

Funding Information:
This work was supported by state and federal funds appropriated to the Ohio Agricultural Research and Development Center (OARDC). Research in SS laboratory is supported through OARDC Competitive Research Enhancement Grants and the Johne's disease integrated program grant (USDA-NRICAP).

Keywords

  • Amplified fragment length polymorphism
  • Crohn's disease
  • Diversity
  • Genotyping
  • Johne's disease

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