TY - JOUR
T1 - Cutting edge
T2 - Evidence for nonvascular route of visceral organ immunosurveillance by T cells
AU - Steinert, Elizabeth M.
AU - Thompson, Emily A.
AU - Beura, Lalit K.
AU - Adam, Omar A.
AU - Mitchell, Jason S.
AU - Guo, Mengdi
AU - Breed, Elise R.
AU - Sjaastad, Frances V.
AU - Vezys, Vaiva
AU - Masopust, David
N1 - Funding Information:
This work was supported by National Institutes of Health Grants R01AI111671 and R01AI084913 (to D.M.) and a University of Minnesota Doctoral Dissertation Fellowship (to E.M.S. and E.A.T.).
Publisher Copyright:
Copyright © 2018 by The American Association of Immunologists, Inc.
PY - 2018/7/15
Y1 - 2018/7/15
N2 - Lymphocytes enter tissues from blood vessels through a well-characterized three-step process of extravasation. To our knowledge, nonvascular routes of lymphocyte entry have not been described. In this article, we report that Ag-experienced CD8 T cells in mice recirculate from blood through the peritoneal cavity. In the event of infection, Ag-experienced CD8 T cell subsets adhered to visceral organs, indicating potential transcapsular immunosurveillance. Focusing on the male genital tract (MGT), we observed Ag-experienced CD8 T cell migration from the peritoneal cavity directly to the infected MGT across the capsule, which was dependent on the extracellular matrix receptor CD44. We also observed that, following clearance of infection, the MGT retained functional resident memory CD8 T cells. These data suggest that recirculation through body cavities may provide T cells with opportunities for broad immunosurveillance and potential nonvascular mechanisms of entry.
AB - Lymphocytes enter tissues from blood vessels through a well-characterized three-step process of extravasation. To our knowledge, nonvascular routes of lymphocyte entry have not been described. In this article, we report that Ag-experienced CD8 T cells in mice recirculate from blood through the peritoneal cavity. In the event of infection, Ag-experienced CD8 T cell subsets adhered to visceral organs, indicating potential transcapsular immunosurveillance. Focusing on the male genital tract (MGT), we observed Ag-experienced CD8 T cell migration from the peritoneal cavity directly to the infected MGT across the capsule, which was dependent on the extracellular matrix receptor CD44. We also observed that, following clearance of infection, the MGT retained functional resident memory CD8 T cells. These data suggest that recirculation through body cavities may provide T cells with opportunities for broad immunosurveillance and potential nonvascular mechanisms of entry.
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U2 - 10.4049/jimmunol.1800279
DO - 10.4049/jimmunol.1800279
M3 - Article
C2 - 29875151
AN - SCOPUS:85049865273
SN - 0022-1767
VL - 201
SP - 337
EP - 342
JO - Journal of Immunology
JF - Journal of Immunology
IS - 2
ER -