Triiodothyronine (T3), the active thyroid hormone, reduced cytochrome c non-enzymatically. This reduction was partially inhibited by superoxide dismutase (SOD). Thyroxine (T4) was only minimally effective as a reductant in this system. The effect of T3 on mitochondrial oxidative phosphorylation may involve a direct redox mechanism.
Bibliographical noteFunding Information:
I am most appreciative of the helpful comments of Dr. S. Schwartz. I also wish to thank B. Stephenson, P. Edmondson, J. De Lue, and J. Mack and associates for technical assistance. These studies, carried out in the laboratories of the Minneapolis Medical Research Foundation, were partially supported by USPHS Grant AM12466 to S. Schwartz.
- Cytochrome c
- Oxidative phosphorylation
- Thyroxine (T)
- Triiodothyronine (T)