Cytokine and chemokine levels in patients infected with the novel avian influenza a (H7N9) virus in China

Ying Chi, Yefei Zhu, Tian Wen, Lunbiao Cui, Yiyue Ge, Yongjun Jiao, Tao Wu, Aihua Ge, Hong Ji, Ke Xu, Changjun Bao, Zheng Zhu, Xian Qi, Bin Wu, Zhiyang Shi, Fenyang Tang, Zheng Xing, Minghao Zhou

Research output: Contribution to journalArticlepeer-review

63 Scopus citations

Abstract

H7N9 avian influenza is an emerging viral disease in China caused by avian influenza A (H7N9) virus. We investigated host cytokine and chemokine profiles in serum samples of H7N9 patients by multiplex-microbead immunoassays. Statistical analysis showed that IP-10, IL-6, IL-17, and IL-2 were increased in H7N9 infected patients. Furthermore, IL-6 and the chemokine IP-10 were significantly higher in severe H7N9 patients compared to nonsevere H7N9 cases. We suggest that proinflammatory cytokine responses, characterized by a combined Th1/Thl7 cytokine induction, are partially responsible for the disease progression of patients with H7N9 infection.

Original languageEnglish (US)
Pages (from-to)1962-1967
Number of pages6
JournalJournal of Infectious Diseases
Volume208
Issue number12
DOIs
StatePublished - Dec 15 2013

Bibliographical note

Funding Information:
Financial support. This work was supported by National Major Science and Technology Projects for Infectious Disease Control and Prevention (2013ZX10004103-006), the Jiangsu Province Health Development Project with Science and Education (ZX201109, RC2011082, RC2011191, RC2011084, RC2011085, JKRC2011001) and the Science and Technology Pillar program of Jiangsu Province (BE2011796). Potential conflicts of interest. All authors: No reported conflicts.

Keywords

  • Chemokine
  • Cytokine
  • H7N9 avian influenza

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