TY - JOUR
T1 - d-Amphetamine and phencyclidine alone and in combination
T2 - Effects on fixed-ratio and interresponse-time-greater-than-t responding of rats
AU - Poling, Alan
AU - Cleary, James
AU - Jackson, Kevin
AU - Wallace, Scott
PY - 1981/9
Y1 - 1981/9
N2 - The effects of three doses of d-amphetamine (0.5, 1.0, and 2.0 mg/kg) and phencylidine (0.5, 1.0, and 2.0 mg/kg), alone and in combination, were assessed in rats performing under fixed-ratio 30 and interresponse-time-greater-than-15-sec food reinforcement schedules. When given alone, phencyclidine and d-amphetamine produced similar increases in responding under the interresponse-time-greater-than-t schedule, and decreases in responding under the fixed-ration 30 schedule. Each drug decreased the number of reinforcers (food pellets) earned relative to control values under both schedules. The effects of the two drugs in combination were nearly always less than additive. That is, the effects of a given dose of phencyclidine and d-amphetamine together were less than an arithmetic summation of the effects of the drugs given alone.
AB - The effects of three doses of d-amphetamine (0.5, 1.0, and 2.0 mg/kg) and phencylidine (0.5, 1.0, and 2.0 mg/kg), alone and in combination, were assessed in rats performing under fixed-ratio 30 and interresponse-time-greater-than-15-sec food reinforcement schedules. When given alone, phencyclidine and d-amphetamine produced similar increases in responding under the interresponse-time-greater-than-t schedule, and decreases in responding under the fixed-ration 30 schedule. Each drug decreased the number of reinforcers (food pellets) earned relative to control values under both schedules. The effects of the two drugs in combination were nearly always less than additive. That is, the effects of a given dose of phencyclidine and d-amphetamine together were less than an arithmetic summation of the effects of the drugs given alone.
KW - Fixed-ratio schedule
KW - Interresponse-time-greater-than-t schedule
KW - Operant behavior
KW - Phencyclidine
KW - Rats
KW - Schedule-controlled behavior
KW - d-Amphetamine
KW - drug interactions
UR - http://www.scopus.com/inward/record.url?scp=0019409071&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0019409071&partnerID=8YFLogxK
U2 - 10.1016/0091-3057(81)90262-8
DO - 10.1016/0091-3057(81)90262-8
M3 - Article
C2 - 7291238
AN - SCOPUS:0019409071
SN - 0091-3057
VL - 15
SP - 357
EP - 361
JO - Pharmacology, Biochemistry and Behavior
JF - Pharmacology, Biochemistry and Behavior
IS - 3
ER -