[D-Thr2, Thz5]-enkephalinamide: A potent analgesic by subcutaneous and oral administration

Liang Fu Tseng; Horace H. Loh; Choh Hao Li

doi:10.1016/0024-3205(78)90238-2

[D-Thr², Thz⁵]-enkephalinamide: A potent analgesic by subcutaneous and oral administration

Liang Fu Tseng, Horace H. Loh, Choh Hao Li

Pharmacology

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

[D-Thr², Thz⁵]-enkephalinamide administered orally or subcutaneously inhibited the tail-flick response to heat stimuli in mice. On a molar basis, this peptide was found to be 1.5-1.7 times more potent than morphine by oral administration.

Original language	English (US)
Pages (from-to)	2053-2056
Number of pages	4
Journal	Life Sciences
Volume	23
Issue number	20
DOIs	https://doi.org/10.1016/0024-3205(78)90238-2
State	Published - Nov 13 1978

Bibliographical note

Funding Information:
This work was supported in part by grants from NIDA No . DA-01314 (to L-F . T,), DA-00564 (to H .H .L .), NIMH MH-30245 and Hormone Research Foundation (to C .H .L .) .

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title = "[D-Thr2, Thz5]-enkephalinamide: A potent analgesic by subcutaneous and oral administration",

abstract = "[D-Thr2, Thz5]-enkephalinamide administered orally or subcutaneously inhibited the tail-flick response to heat stimuli in mice. On a molar basis, this peptide was found to be 1.5-1.7 times more potent than morphine by oral administration.",

author = "Tseng, {Liang Fu} and Loh, {Horace H.} and Li, {Choh Hao}",

note = "Funding Information: This work was supported in part by grants from NIDA No . DA-01314 (to L-F . T,), DA-00564 (to H .H .L .), NIMH MH-30245 and Hormone Research Foundation (to C .H .L .) .",

year = "1978",

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T2 - A potent analgesic by subcutaneous and oral administration

AU - Tseng, Liang Fu

AU - Loh, Horace H.

AU - Li, Choh Hao

N1 - Funding Information: This work was supported in part by grants from NIDA No . DA-01314 (to L-F . T,), DA-00564 (to H .H .L .), NIMH MH-30245 and Hormone Research Foundation (to C .H .L .) .

PY - 1978/11/13

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N2 - [D-Thr2, Thz5]-enkephalinamide administered orally or subcutaneously inhibited the tail-flick response to heat stimuli in mice. On a molar basis, this peptide was found to be 1.5-1.7 times more potent than morphine by oral administration.

AB - [D-Thr2, Thz5]-enkephalinamide administered orally or subcutaneously inhibited the tail-flick response to heat stimuli in mice. On a molar basis, this peptide was found to be 1.5-1.7 times more potent than morphine by oral administration.

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