Abstract
Sensitization of resistant bacteria to existing antibiotics depends on the identification of candidate targets whose activities contribute to resistance. Using a transposon insertion library in an Escherichia coli mutant that was 2,000 times less susceptible to ciprofloxacin than its parent and the relative fitness scores, we identified 19 genes that contributed to the acquired ciprofloxacin resistance and mapped the shortest genetic path that increased the antibiotic susceptibility of the resistant bacteria back to a near wild-type level.
Original language | English (US) |
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Pages (from-to) | 6353-6355 |
Number of pages | 3 |
Journal | Antimicrobial agents and chemotherapy |
Volume | 60 |
Issue number | 10 |
DOIs | |
State | Published - Oct 2016 |
Bibliographical note
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