TY - JOUR
T1 - De Novo Immunotactoid Glomerulopathy of the Renal Allograft
T2 - Possible Association With Cytomegalovirus Infection
AU - Rao, K. Venkateswara
AU - Hafner, Gerard P.
AU - Crary, Gretchen S.
AU - Anderson, W. Robert
AU - Crosson, John T.
PY - 1994
Y1 - 1994
N2 - A 59-year-old man with end-stage renal failure from systemic vasculitis developed de novo immunotactoid glomerulopathy of the renal allograft, with clinical evidence of hematuria, proteinuria, and acute renal failure 6 weeks after cadaveric renal transplantation. The morphologic lesion of immunotactoid glomerulopathy and the clinical renal disease resolved during the following 2 weeks. The disease had not recurred in the subsequent 20 months of posttransplant follow-up. During the same period, the patient also developed systemic cytomegalovirus (CIVIV) infection with viremia, acute hepatitis, and bone marrow suppression. The clinical manifestations of CMV illness and the renal disease have subsided following the withdrawal of immunosuppressive agents and simultaneous treatment with ganciclovir. Although there is no direct proof that CMV infection was responsible for the development of immunotactoid glomerulopathy, the circumstantial evidence in this patient strongly suggests that these two disease were temporally linked. To our knowledge, the association between CMV infection and immunotactoid glomerulopathy has not been documented previously.
AB - A 59-year-old man with end-stage renal failure from systemic vasculitis developed de novo immunotactoid glomerulopathy of the renal allograft, with clinical evidence of hematuria, proteinuria, and acute renal failure 6 weeks after cadaveric renal transplantation. The morphologic lesion of immunotactoid glomerulopathy and the clinical renal disease resolved during the following 2 weeks. The disease had not recurred in the subsequent 20 months of posttransplant follow-up. During the same period, the patient also developed systemic cytomegalovirus (CIVIV) infection with viremia, acute hepatitis, and bone marrow suppression. The clinical manifestations of CMV illness and the renal disease have subsided following the withdrawal of immunosuppressive agents and simultaneous treatment with ganciclovir. Although there is no direct proof that CMV infection was responsible for the development of immunotactoid glomerulopathy, the circumstantial evidence in this patient strongly suggests that these two disease were temporally linked. To our knowledge, the association between CMV infection and immunotactoid glomerulopathy has not been documented previously.
KW - Transplantation, renal, homologous
KW - cytomegalovirus infection
KW - immunotactoid glomerulopathy
KW - pathology, kidney
KW - transplantation, human, complications
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U2 - 10.1016/S0272-6386(12)80167-3
DO - 10.1016/S0272-6386(12)80167-3
M3 - Article
C2 - 8023832
AN - SCOPUS:0028357414
SN - 0272-6386
VL - 24
SP - 97
EP - 103
JO - American Journal of Kidney Diseases
JF - American Journal of Kidney Diseases
IS - 1
ER -