Abstract
The deamination of cyclaradine corresponding to a carbocyclic analogue of ara-A having anti-HSV activity by adenosine deaminase was examined under various pressure. The deamination of (+)- and (±)-cyclaradine was remarkably facilitated by high pressure, and the rate was increased with increasing of pressure. However, (-)-cyclaradine was not deaminated even under high pressure.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-89 |
| Number of pages | 9 |
| Journal | Nucleosides and Nucleotides |
| Volume | 17 |
| Issue number | 1-3 |
| State | Published - Apr 8 1998 |