Abstract
(Chemical Equation Presented) N-Acyl-2-oxazolidinones are ring-opened by lithium iodide and decarboxylated in the presence of a mild proton source. Further reaction with an amine base provides 2-oxazolines. The transformation is general for oxazolidinones unsubstituted in the 5 position and occurs under mild conditions (25-50°C). These results complement the existing methods for this transformation by allowing lower temperatures and/or avoiding metal catalysts.
Original language | English (US) |
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Pages (from-to) | 3292-3294 |
Number of pages | 3 |
Journal | Journal of Organic Chemistry |
Volume | 73 |
Issue number | 8 |
DOIs | |
State | Published - Apr 18 2008 |