Decreased gray matter in normal aging: An in vivo magnetic resonance study

K. O. Lim, R. B. Zipursky, M. C. Watts, A. Pfefferbaum

Research output: Contribution to journalArticlepeer-review

81 Scopus citations

Abstract

Using in vivo magnetic resonance (MR) images, the percentages of gray matter, white matter, and cerebrospinal fluid (CSF) in the brains of 8 young and 6 elderly normal male community volunteers were quantified. Compared with the young men, the elderly men had a significantly lower percentage of gray matter (p < .01) and higher percentage of CSF (p < .01). The percentage of white matter was not significantly different between the two groups. This finding suggests that the age-related decrease in brain tissue is chiefly due to loss of gray matter.

Original languageEnglish (US)
Pages (from-to)B26-B30
JournalJournals of Gerontology
Volume47
Issue number1
DOIs
StatePublished - 1992

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