Defective lymphoid development in mice lacking Jak3

Tetsuya Nosaka, Jan M.A. Van Deursen, Ralph A. Tripp, William E. Thierfelder, Bruce A. Witthuhn, Anthony P. McMickle, Peter C. Doherty, Gerard C. Grosveld, James N. Ihle

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527 Scopus citations

Abstract

The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common γ (γc) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting. Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in γc signaling and lymphoid development.

Original languageEnglish (US)
Pages (from-to)800-802
Number of pages3
JournalScience
Volume270
Issue number5237
DOIs
StatePublished - 1995

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