TY - JOUR
T1 - Defective lymphoid development in mice lacking Jak3
AU - Nosaka, Tetsuya
AU - Van Deursen, Jan M.A.
AU - Tripp, Ralph A.
AU - Thierfelder, William E.
AU - Witthuhn, Bruce A.
AU - McMickle, Anthony P.
AU - Doherty, Peter C.
AU - Grosveld, Gerard C.
AU - Ihle, James N.
PY - 1995/11/3
Y1 - 1995/11/3
N2 - The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common γ(γ(c)) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting, Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in γ(c) signaling and lymphoid development.
AB - The Janus tyrosine kinases (Jaks) play a central role in signaling through cytokine receptors. Although Jak1, Jak2, and Tyk2 are widely expressed, Jak3 is predominantly expressed in hematopoietic cells and is known to associate only with the common γ(γ(c)) chain of the interleukin (IL)-2, IL-4, IL-7, IL-9, and IL-15 receptors. Homozygous mutant mice in which the Jak3 gene had been disrupted were generated by gene targeting, Jak3-deficient mice had profound reductions in thymocytes and severe B cell and T cell lymphopenia similar to severe combined immunodeficiency disease (SCID), and the residual T cells and B cells were functionally deficient. Thus, Jak3 plays a critical role in γ(c) signaling and lymphoid development.
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M3 - Article
C2 - 7481769
AN - SCOPUS:0028840706
SN - 0036-8075
VL - 270
SP - 800
EP - 802
JO - Science
JF - Science
IS - 5237
ER -
