TY - JOUR
T1 - Definition and diagnostic criteria of sleep-related hypermotor epilepsy
AU - Tinuper, Paolo
AU - Bisulli, Francesca
AU - Cross, J. H.
AU - Hesdorffer, Dale
AU - Kahane, Philippe
AU - Nobili, Lino
AU - Provini, Federica
AU - Scheffer, Ingrid E.
AU - Tassi, Laura
AU - Vignatelli, Luca
AU - Bassetti, Claudio
AU - Cirignotta, Fabio
AU - Derry, Christopher
AU - Gambardella, Antonio
AU - Guerrini, Renzo
AU - Halasz, Peter
AU - Licchetta, Laura
AU - Mahowald, Mark
AU - Manni, Raffaele
AU - Marini, Carla
AU - Mostacci, Barbara
AU - Naldi, Ilaria
AU - Parrino, Liborio
AU - Picard, Fabienne
AU - Pugliatti, Maura
AU - Ryvlin, Philippe
AU - Vigevano, Federico
AU - Zucconi, Marco
AU - Berkovic, Samuel
AU - Ottman, Ruth
N1 - Publisher Copyright:
© 2016 American Academy of Neurology.
PY - 2016/5/10
Y1 - 2016/5/10
N2 - The syndrome known as nocturnal frontal lobe epilepsy is recognized worldwide and has been studied in a wide range of clinical and scientific settings (epilepsy, sleep medicine, neurosurgery, pediatric neurology, epidemiology, genetics). Though uncommon, it is of considerable interest to practicing neurologists because of complexity in differential diagnosis from more common, benign sleep disorders such as parasomnias, or other disorders like psychogenic nonepileptic seizures.Moreover, misdiagnosis can have substantial adverse consequences on patients' lives. At present, there is no consensus definition of this disorder and disagreement persists about its core electroclinical features and the spectrum of etiologies involved. To improve the definition of the disorder and establish diagnostic criteria with levels of certainty, a consensus conference using formal recommended methodology was held in Bologna in September 2014. It was recommended that the name be changed to sleep-related hypermotor epilepsy (SHE), reflecting evidence that the attacks are associated with sleep rather than time of day, the seizures may arise from extrafrontal sites, and the motor aspects of the seizures are characteristic. The etiology may be genetic or due to structural pathology, but in most cases remains unknown. Diagnostic criteria were developed with 3 levels of certainty: witnessed (possible) SHE, video-documented (clinical) SHE, and video-EEG-documented (confirmed) SHE. Themain research gaps involve epidemiology, pathophysiology, treatment, and prognosis.
AB - The syndrome known as nocturnal frontal lobe epilepsy is recognized worldwide and has been studied in a wide range of clinical and scientific settings (epilepsy, sleep medicine, neurosurgery, pediatric neurology, epidemiology, genetics). Though uncommon, it is of considerable interest to practicing neurologists because of complexity in differential diagnosis from more common, benign sleep disorders such as parasomnias, or other disorders like psychogenic nonepileptic seizures.Moreover, misdiagnosis can have substantial adverse consequences on patients' lives. At present, there is no consensus definition of this disorder and disagreement persists about its core electroclinical features and the spectrum of etiologies involved. To improve the definition of the disorder and establish diagnostic criteria with levels of certainty, a consensus conference using formal recommended methodology was held in Bologna in September 2014. It was recommended that the name be changed to sleep-related hypermotor epilepsy (SHE), reflecting evidence that the attacks are associated with sleep rather than time of day, the seizures may arise from extrafrontal sites, and the motor aspects of the seizures are characteristic. The etiology may be genetic or due to structural pathology, but in most cases remains unknown. Diagnostic criteria were developed with 3 levels of certainty: witnessed (possible) SHE, video-documented (clinical) SHE, and video-EEG-documented (confirmed) SHE. Themain research gaps involve epidemiology, pathophysiology, treatment, and prognosis.
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U2 - 10.1212/WNL.0000000000002666
DO - 10.1212/WNL.0000000000002666
M3 - Review article
C2 - 27164717
AN - SCOPUS:84978375350
SN - 0028-3878
VL - 86
SP - 1834
EP - 1842
JO - Neurology
JF - Neurology
IS - 19
ER -