Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications

Abbas Raza; Robert Vince

doi:10.1002/cbic.201000748

Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications

Abbas Raza, Robert Vince

Center for Drug Design

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

In addition to being an antioxidant, ascorbic acid in its oxidized form, dehydroascorbic acid (DHA) can alter DNA or RNA function, such as protein biosynthesis upon binding to guanosine. Here we show the EC₅₀ of DHA on different protein systems and X-ray crystal structure of the isolated adduct of dehydroascorbic acid and 9-ethylguanine (see figure).

Original language	English (US)
Pages (from-to)	1015-1017
Number of pages	3
Journal	ChemBioChem
Volume	12
Issue number	7
DOIs	https://doi.org/10.1002/cbic.201000748
State	Published - May 2 2011

Keywords

Crystal structure
Dehydroascorbic acid
Nucleic acids
Nucleobases
Reticulocytes
Vitamins

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KW - Crystal structure

KW - Dehydroascorbic acid

KW - Nucleic acids

KW - Nucleobases

KW - Reticulocytes

KW - Vitamins

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Dehydroascorbic Acid Adducts of Guanosine Residues: Possible Biological Implications

Abstract

Keywords

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