Dehydroepiandrosterone and related steroids inhibit mitochondrial respiration in vitro

Pamarthi F. Mohan, Margot P. Cleary

Research output: Contribution to journalArticlepeer-review

22 Scopus citations

Abstract

1. 1. Dehydroepiandrosterone (DHEA) inhibited mitochondrial respiratory rates in the presence of tricarboxylic acid cycle intermediates with the exception of succinate. 2. 2. Several other steroids tested for inhibitory activity on mitochondrial state 3 rate showed inhibitory potencies ranging from 0-90%. 3. 3. Mitochondria isolated from adrenals, heart, kidneys, brain and brown adipose tissue were also inhibited by DHEA. 4. 4. The aspartate-malate shuttle system was inhibited, but the α-glycerophosphate shuttle was totally insensitive to DHEA. 5. 5. The high-amplitude swelling of mitochondria in hypotonic media was inhibited by DHEA and a few other steroids.

Original languageEnglish (US)
Pages (from-to)1103-1107
Number of pages5
JournalInternational Journal of Biochemistry
Volume21
Issue number10
DOIs
StatePublished - 1989

Bibliographical note

Funding Information:
Acknowledgemenfs-This work was supported by United States Public Health Service Grant HL08214 from the Program Projects Branch, Extramural Programs, National Heart, Lung and Blood Institute, and by The Hormel Foundation.

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