Dependence of Punch Sticking on Compaction Pressure—Roles of Particle Deformability and Tablet Tensile Strength

Shubhajit Paul, Kunlin Wang, Lisa J. Taylor, Brendan Murphy, Joseph Krzyzaniak, Neil Dawson, Matthew P. Mullarney, Paul Meenan, Changquan Calvin Sun

Research output: Contribution to journalArticlepeer-review

14 Scopus citations

Abstract

Punch sticking is a complex phenomenon influenced primarily by particle size, tooling surface roughness, tooling design, and tooling construction material. When particle and environmental factors are controlled, compaction pressure has a distinct effect on punch sticking behavior for a given active pharmaceutical ingredient (API). This research focuses on the effect of compaction pressure on punch sticking using 5 compounds with different sticking propensities. The results collectively show that sticking tends to be more problematic under higher compaction pressures and for more ductile compounds. This is attributed to the greater punch surface coverage by the API and the stronger cohesion of API to the existing API layer on the punch.

Original languageEnglish (US)
Pages (from-to)2060-2067
Number of pages8
JournalJournal of Pharmaceutical Sciences
Volume106
Issue number8
DOIs
StatePublished - Aug 2017

Keywords

  • bonding strength
  • compression
  • plastic deformation
  • pressure
  • punch sticking
  • surface area

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