TY - JOUR
T1 - Derivation of LIF-independent mouse iPS cells with modified Oct4
AU - Hirai, Hiroyuki
AU - Firpo, Meri
AU - Kikyo, Nobuaki
N1 - Publisher Copyright:
© 2015 The Authors.
PY - 2015/9/1
Y1 - 2015/9/1
N2 - It has been very difficult, if not impossible, to establish mouse induced pluripotent stem cells (iPSCs) from differentiated cells, such as fibroblasts, without leukemia inhibitory factor (LIF). We have established and maintained LIF-independent iPSCs for longer than 120. days with modified Oct4 along with Sox2, Klf4, and c-Myc. The iPSCs will provide a novel tool to investigate the roles of the LIF-Stat3 signaling pathway in mouse pluripotent stem cells.
AB - It has been very difficult, if not impossible, to establish mouse induced pluripotent stem cells (iPSCs) from differentiated cells, such as fibroblasts, without leukemia inhibitory factor (LIF). We have established and maintained LIF-independent iPSCs for longer than 120. days with modified Oct4 along with Sox2, Klf4, and c-Myc. The iPSCs will provide a novel tool to investigate the roles of the LIF-Stat3 signaling pathway in mouse pluripotent stem cells.
UR - http://www.scopus.com/inward/record.url?scp=84940106017&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84940106017&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2015.08.005
DO - 10.1016/j.scr.2015.08.005
M3 - Article
C2 - 26318720
AN - SCOPUS:84940106017
SN - 1873-5061
VL - 15
SP - 384
EP - 386
JO - Stem Cell Research
JF - Stem Cell Research
IS - 2
ER -
