Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease

Jeffrey A. Allen; Steven A. Greenberg; Anthony A. Amato

doi:10.1002/mus.21353

Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease

Jeffrey A. Allen, Steven A. Greenberg, Anthony A. Amato

Neurology

Research output: Contribution to journal › Article › peer-review

17 Scopus citations

Abstract

Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.

Original language	English (US)
Pages (from-to)	643-647
Number of pages	5
Journal	Muscle and Nerve
Volume	40
Issue number	4
DOIs	https://doi.org/10.1002/mus.21353
State	Published - Oct 2009

Keywords

Chronic graft-versus-host disease
Dermatomyositis
Hematopoietic stem cell transplantation
Myositis
Perifascicular atrophy

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title = "Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease",

abstract = "Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.",

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AB - Myositis is a rare complication of chronic graft-versus-host disease (cGVHD) following hematopoietic stem cell transplantation (HSCT). Almost all such patients have been reported to have polymyositis (PM). We describe clinical, pathologic, and molecular studies of 3 patients with cGVHD following allogeneic HSCT who developed myopathy. In each case, perifascicular atrophy, the pathognomonic histologic feature of dermatomyositis (DM), was observed.

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KW - Perifascicular atrophy

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Dermatomyositis-like muscle pathology in patients with chronic graft-versus-host disease

Abstract

Keywords

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