Abstract
A method is proposed for the evaluation of in vitro experiments for combination chemotherapy, a new and growing area of cancer research. We first describe and review a popular graphical device called an isobologram. We then propose a statistical framework, a simple experimental design, and a statistical test for use with this widely accepted methodology. The test we propose is a score test based on the linear logistic regression model.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 179-186 |
| Number of pages | 8 |
| Journal | Journal of Biopharmaceutical Statistics |
| Volume | 15 |
| Issue number | 1 |
| DOIs | |
| State | Published - 2005 |
Keywords
- Combination chemotherapy
- Drug potency
- Isobologram
- Synergism
