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Abstract
A set of poly(δ-valerolactone-co-d,l-lactide)-b-poly(ethylene glycol)-b-poly(δ-valerolactone-co-d,l-lactide) (PVLA-PEG-PVLA) triblock copolymers was synthesized and the solution properties were characterized using rheology, cryo-TEM, cryo-SEM, SANS, and degradation studies. This polymer self-assembles into a low viscosity fluid with flowerlike spherical micelles in water at room temperature and transforms into a wormlike morphology upon heating, accompanied by gelation. At even higher temperatures syneresis is observed. At physiological temperature (37 °C) the hydrogel's average pore size is around 600 nm. The PVLA-PEG-PVLA gel degrades in about 45 days in cell media, making this unique hydrogel a promising candidate for biomedical applications.
Original language | English (US) |
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Pages (from-to) | 1134-1139 |
Number of pages | 6 |
Journal | ACS Macro Letters |
Volume | 6 |
Issue number | 10 |
DOIs | |
State | Published - Oct 17 2017 |
Bibliographical note
Publisher Copyright:© 2017 American Chemical Society.
How much support was provided by MRSEC?
- Partial
Reporting period for MRSEC
- Period 4
Fingerprint
Dive into the research topics of 'Design and Characterization of a PVLA-PEG-PVLA Thermosensitive and Biodegradable Hydrogel'. Together they form a unique fingerprint.-
MRSEC IRG-3: Hierarchical Multifunctional Macromolecular Materials
Reineke, T. M., Bates, F. S., Dorfman, K., Dutcher, C. S., Hillmyer, M. A., Lodge, T., Morse, D. C., Siepmann, I., Barreda, L. & Ganewatta, M. S.
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Project: Research project
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