Design and synthesis of dual inhibitors of HIV reverse transcriptase and integrase: Introducing a diketoacid functionality into delavirdine

Medicine & Life Sciences

• Delavirdine 94%
• HIV Reverse Transcriptase 83%
• Integrases 71%
• HIV 37%
• Reverse Transcriptase Inhibitors 33%
• RNA-Directed DNA Polymerase 32%
• Enzyme Assays 31%
• Highly Active Antiretroviral Therapy 30%
• Acquired Immunodeficiency Syndrome 22%
• Ligands 19%
• Costs and Cost Analysis 17%
• Therapeutics 4%

Chemical Compounds

• Delavirdine 100%
• Antiretroviral 78%
• Ligand 24%