Design of organocatalysts for asymmetric direct syn-aldol reactions

Xiao Ying Xu; Yanzhao Wang; Liu Zhu Gong

doi:10.1021/ol701798x

Design of organocatalysts for asymmetric direct syn-aldol reactions

Xiao Ying Xu, Yanzhao Wang, Liu Zhu Gong

Chemistry (Twin Cities)

Research output: Contribution to journal › Article › peer-review

142 Scopus citations

Abstract

Two new organocatalysts 3a and 3b, derived from L-leucine and (S)-β-amino alcohols that were prepared from L-valine, were designed and afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with an excellent diastereomeric ratio of up to >20/1 and enantioselectivities of up to 99% ee.

Original language	English (US)
Pages (from-to)	4247-4249
Number of pages	3
Journal	Organic Letters
Volume	9
Issue number	21
DOIs	https://doi.org/10.1021/ol701798x
State	Published - Oct 11 2007

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abstract = "Two new organocatalysts 3a and 3b, derived from L-leucine and (S)-β-amino alcohols that were prepared from L-valine, were designed and afforded the direct syn-aldol reactions of a wide scope of aldehydes with various ketones with an excellent diastereomeric ratio of up to >20/1 and enantioselectivities of up to 99% ee.",

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Design of organocatalysts for asymmetric direct syn-aldol reactions

Abstract

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