Designing a pronucleotide stratagem: Lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines

Dan P. Drontle; Carston R. Wagner

doi:10.2174/1389557043403945

Designing a pronucleotide stratagem: Lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines

Dan P. Drontle, Carston R. Wagner

Medicinal Chemistry

Research output: Contribution to journal › Review article › peer-review

70 Scopus citations

Abstract

Phosphoramidate pronucleotides have proven to be an effective strategy for the intracellular delivery of nucleoside 5′-monophosphates. This review will summarize our efforts to understand the in vitro and in vivo behavior of phosphoramidate monoesters of 3′-azido-3′-deoxythymidine (AZT), 3′ -fluoro-3′-deoxythymidine (FLT) and 5-fluoro-2′-deoxyuridine (FUdR). Insights drawn from these studies have proved valuable for the future design of phosphoramidate-based pronucleotides.

Original language	English (US)
Pages (from-to)	409-419
Number of pages	11
Journal	Mini-Reviews in Medicinal Chemistry
Volume	4
Issue number	4
DOIs	https://doi.org/10.2174/1389557043403945
State	Published - May 2004

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Designing a pronucleotide stratagem: Lessons from amino acid phosphoramidates of anticancer and antiviral pyrimidines

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