Desmethylubiquinone Q 2 from the Far-Eastern ascidian Aplidium glabrum: Structure and synthesis

Larisa K. Shubina, Sergey N. Fedorov, Oleg S. Radchenko, Nadezhda N. Balaneva, Sophia A. Kolesnikova, Pavel S. Dmitrenok, Ann Bode, Zigang Dong, Valentin A. Stonik

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Two new diprenylquinones, glabruquinone A (desmethylubiquinone Q 2) having cancer preventive properties and its minor isomer Glabruquinone B were isolated from the ascidian Aplidium glabrum. Their structures have been elucidated by NMR and mass spectra and confirmed by synthesis.

Original languageEnglish (US)
Pages (from-to)559-562
Number of pages4
JournalTetrahedron Letters
Issue number4
StatePublished - Jan 24 2005

Bibliographical note

Funding Information:
We are grateful to B. B. Grebnev for identification of the ascidian. The research described in this publication was made possible in part by Grant NS-725.2003.4 of RFBR and a Grant from the Program ‘Molecular and cell biology of RAS’.


  • Cancer preventive activity
  • Marine natural products
  • Polyprenylated quinones
  • Synthesis


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