We report a chemically tunable electronic sensor for quantitation of gluten based on a floating-gate transistor (FGT) architecture. The FGTs are fabricated in parallel and each one is functionalized with a different chemical moiety designed to preferentially bind a specific grain source of gluten. The resulting set of FGT sensors can detect both wheat and barley gluten below the gluten-free limit of 20 ppm (w/w) while providing a source-dependent signature for improved accuracy. This label-free transduction method does not require any secondary binding events, resulting in a ca. 45 min reduction in analysis time relative to state-of-the-art ELISA kits with a simple and easily implemented workflow.
Bibliographical noteFunding Information:
We acknowledge funding from the National Science Foundation (Predoctoral Fellowship for SPW), the University of Minnesota MN-Drive program, and the Office of Naval Research through the Multi-University Research Initiative (CDF). A portion of this work was performed at the University of Minnesota Nanofabrication Center which received partial support from the NSF through NNIN.
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