Abstract
Eighty breast cancer specimens were examined for insulin-like growth factor binding protein (IGFBP) expression by ligand blotting. Five distinct IGFBP species were found: a doublet at 48 and 44 kDa was IGFBP-3, the 34-kDa band was IGFBP-2, and a band at 24 kDa was IGFBP-4. A 32-kDa band was compatible with the migration position reported for IGFBP-5. IGFBP-3 was inversely correlated with ER expression, while IGFBP-4 was positively correlated with both ER and PgR. IGFBP-4 was also inversely correlated with S-phase fraction. Thus, IGFBP expression correlates with other parameters of breast cancer biology and may play a role in regulating tumor growth.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 25-32 |
| Number of pages | 8 |
| Journal | Cancer Letters |
| Volume | 77 |
| Issue number | 1 |
| DOIs | |
| State | Published - Feb 28 1994 |
Bibliographical note
Funding Information:Douglas Yee is a Pew Scholar in the Biomedical Sciencesa nd recipient of an NIH Research Career Development Award. This work was supported by grants R29 CA52592 and PO1 CA30195 and a cancer center support grant to the Cancer Therapy and Research Center. Jose A. Figueroa is supported by an NRSA training grant, CA09434.
Keywords
- Breast cancer
- Estrogen receptor
- Insulin-like growth factor binding proteins
- Progesterone receptor
- S-phase fraction
