Deterioration of Vestibular Cells in Labyrinthitis

Serdar Kaya, Patricia A. Schachern, Vladimir Tsuprun, Michael M. Paparella, Sebahattin Cureoglu

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Objective: To quantitatively assess the effect of serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans on vestibular hair cells, dark cells, and transitional cells. Methods: We examined human temporal bone specimens with serous labyrinthitis, suppurative labyrinthitis, and labyrinthitis ossificans, then compared them with age-matched control groups without labyrinthitis. We evaluated the density of type I and II vestibular hair cells, dark cells, and transitional cells in the peripheral sensorial organs. Results: The mean density of type I vestibular hair cells in the maculae of the saccule significantly differed between the serous labyrinthitis group and its control group. The loss of type I and II vestibular hair cells in all of the peripheral sensorial organs was significantly higher in the suppurative labyrinthitis group than in its control group. The mean density of dark cells in the lateral and posterior semicircular canals was significantly lower in the suppurative labyrinthitis group than in its control group. The mean density of type I and II vestibular hair cells, dark cells, and transitional cells was significantly lower in the labyrinthitis ossificans group than in its control group. Conclusion: The loss of vestibular hair cells and degenerative changes in dark cells and transitional cells could affect vestibular function in patients with labyrinthitis.

Original languageEnglish (US)
Pages (from-to)89-95
Number of pages7
JournalAnnals of Otology, Rhinology and Laryngology
Volume126
Issue number2
DOIs
StatePublished - Feb 2017

Bibliographical note

Funding Information:
This study was funded by the National Institute on Deafness and Other Communication Disorders (NIDCD), Grant number U24 DC011968-01; the International Hearing Foundation; the Starkey Hearing Foundation; the 5M Lions International; and the Scientific and Technological Research Council of Turkey (TUBITAK).

Keywords

  • dark cell
  • hair cell
  • histopathology
  • human temporal bone
  • labyrinthitis
  • transitional cell
  • vestibule

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